Evidence map›Paper›PMID 31182552›Full record

ArticlePediatrics2019

Incidence of Herpes Zoster Among Children: 2003-2014.

Sheila Weinmann, Allison L Naleway, Padma Koppolu, Roger Baxter, Edward A Belongia, Simon J Hambidge, Stephanie A Irving, Michael L Jackson, Nicola P Klein, Bruno Lewin and 5 more

Open access · greenAbstract read
In one paragraph

Article in Pediatrics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 2 pooled it
9.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 2 syntheses or guidelines pooled it, 107 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Varicella zoster virus and the central nervous system.Nature reviews. Microbiology · 2026
    Review
  9. Article
  10. Article
  11. Article
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  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. A fresh look at varicella vaccination.Human vaccines & immunotherapeutics · 2025
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 1 country.

Sheila WeinmannCenter for Health Research, Kaiser Permanente Northwest, Portland, Oregon; sheila.weinmann@kpchr.org.
Allison L NalewayCenter for Health Research, Kaiser Permanente Northwest, Portland, Oregon.
Padma KoppoluCenter for Health Research, Kaiser Permanente Northwest, Portland, Oregon.
Roger BaxterVaccine Study Center, Kaiser Permanente Northern California, Oakland, California.
Edward A BelongiaMarshfield Clinic Research Institute, Marshfield, Wisconsin.
Simon J HambidgeDenver Health, Denver, Colorado.
Stephanie A IrvingCenter for Health Research, Kaiser Permanente Northwest, Portland, Oregon.
Michael L JacksonKaiser Permanente Washington, Seattle, Washington.
Nicola P KleinVaccine Study Center, Kaiser Permanente Northern California, Oakland, California.
Bruno LewinKaiser Permanente Southern California, Pasadena, California.
Elizabeth LilesCenter for Health Research, Kaiser Permanente Northwest, Portland, Oregon.
Mona MarinCenters for Disease Control and Prevention, Atlanta, Georgia; and.
Ning SmithCenter for Health Research, Kaiser Permanente Northwest, Portland, Oregon.
Eric WeintraubCenters for Disease Control and Prevention, Atlanta, Georgia; and.
Colleen ChunDivision of Pediatric Infectious Diseases (Emeritus), Department of Pediatrics, Northwest Permanente, Portland, Oregon.
Kaiser Permanente Center for Health Research · USKaiser Permanente · USCenters for Disease Control and Prevention · USMarshfield Clinic · USUniversity of Colorado Denver · US

Funding

Intramural CDC HHS CC999999
6 · The paper itself

Abstract

BACKGROUND AND

objectivesAfter the 1996 introduction of routine varicella vaccination in the United States, most studies evaluating pediatric herpes zoster (HZ) incidence reported lower incidence over time, with varying degrees of decline. Using the combined databases of 6 integrated health care organizations, we examined HZ incidence in children over a 12-year period in the varicella vaccine era.

methodsThis study included children aged 0 through 17 years from 2003 through 2014. Using electronic medical records, we identified HZ cases through International Classification of Diseases, Ninth Revision diagnosis code 053. We calculated HZ incidence rates per 100 000 person years of health plan membership for all children and among children who were vaccinated versus unvaccinated. We calculated rates for the 12-year period and examined temporal trends. Among children who were vaccinated, we compared HZ rates by month and year of age at vaccination.

resultsThe study included 6 372 067 children with ≥1 month of health plan membership. For the 12-year period, the crude HZ incidence rate for all subjects was 74 per 100 000 person years, and the rate among children who were vaccinated was 38 per 100 000 person years, which was 78% lower than that among children who were unvaccinated (170 per 100 000 person years;

conclusionsWith this population-based study, we confirm the decline in pediatric HZ incidence and the significantly lower incidence among children who are vaccinated, reinforcing the benefit of routine varicella vaccination to prevent pediatric HZ.

Indexed as

AdolescentChickenpox VaccineChildChild, PreschoolFemaleHerpes ZosterHumansIncidenceInfantInfant, NewbornMaleMass VaccinationUnited StatesChickenpox Vaccine

Identifiers

PMID31182552
PMCPMC7748320
OpenAlexW2952890423

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.