Evidence map›Paper›PMID 31182539›Full record

ArticleAntimicrobial agents and chemotherapy2019

The Novel Arylamidine T-2307 Selectively Disrupts Yeast Mitochondrial Function by Inhibiting Respiratory Chain Complexes.

Kohei Yamashita, Taiga Miyazaki, Yoshiko Fukuda, Junichi Mitsuyama, Tomomi Saijo, Shintaro Shimamura, Kazuko Yamamoto, Yoshifumi Imamura, Koichi Izumikawa, Katsunori Yanagihara and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 65 citations in OpenAlex.

  1. Pharmacological advances inJournal of enzyme inhibition and medicinal chemistry · 2026
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  5. Pathogenesis and Triazole Resistance inInfection and drug resistance · 2026
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  6. Review
  7. Inhibitory effect of copper chelators on the budding inAntimicrobial agents and chemotherapy · 2025
    Article
  8. Review
  9. Review
  10. Review
  11. Recent innovations and challenges in the treatment of fungal infections.Frontiers in cellular and infection microbiology · 2025
    Review
  12. Overcoming antifungal resistance inFrontiers in cellular and infection microbiology · 2025
    Review
  13. Review
  14. Review
  15. Fungal lung disease.The European respiratory journal · 2024
    Review
  16. Review
  17. Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Kohei YamashitaDepartment of Pharmacology Research (Toyama Works), Pharmaceutical and Healthcare Research Laboratories, FUJIFILM Corporation, Toyama, Japan.
Taiga MiyazakiDepartment of Respiratory Medicine, Nagasaki University Hospital, Nagasaki, Japan taiga-m@nagasaki-u.ac.jp.ORCID 0000-0002-0962-5758
Yoshiko FukudaDepartment of Sales Promotion, FUJIFILM Toyama Chemical Co., Ltd., Tokyo, Japan.
Junichi MitsuyamaDevelopment Division, FUJIFILM Toyama Chemical Co., Ltd., Tokyo, Japan.
Tomomi SaijoDepartment of Respiratory Medicine, Nagasaki University Hospital, Nagasaki, Japan.
Shintaro ShimamuraDepartment of Respiratory Medicine, Nagasaki University Hospital, Nagasaki, Japan.
Kazuko YamamotoDepartment of Respiratory Medicine, Nagasaki University Hospital, Nagasaki, Japan.
Yoshifumi ImamuraDepartment of Respiratory Medicine, Nagasaki University Hospital, Nagasaki, Japan.
Koichi IzumikawaDepartment of Infectious Diseases, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Katsunori YanagiharaDepartment of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Shigeru KohnoDepartment of Respiratory Medicine, Nagasaki University Hospital, Nagasaki, Japan.
Hiroshi MukaeDepartment of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Nagasaki University Hospital · JPFujifilm (Japan) · JPNagasaki University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The novel arylamidine T-2307 exhibits broad-spectrum

Indexed as

Adenosine TriphosphateAmidinesAnimalsAntifungal AgentsCandida albicansCattleElectron Transport Complex IElectron Transport Complex IIMicrobial Sensitivity TestsMitochondriaMitochondria, HeartMitochondria, LiverNADH DehydrogenaseRatsSaccharomyces cerevisiaeAdenosine TriphosphateAmidinesAntifungal AgentsElectron Transport Complex IElectron Transport Complex IINADH DehydrogenaseT-2307antifungalCandida albicansmechanism of actionrespiratory chainyeast

Identifiers

PMID31182539
PMCPMC6658782
OpenAlexW2953380395

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.