Evidence map›Paper›PMID 31182217›Full record

Trial reportHeart & lung : the journal of critical care

A multi-component, family-focused and literacy-sensitive intervention to improve medication adherence in patients with heart failure-A randomized controlled trial.

Jia-Rong Wu, Barbara Mark, George J Knafl, Sandra B Dunbar, Patricia P Chang, Darren A DeWalt

Abstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Heart & lung : the journal of critical care. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Trial
  7. From optimistic to overwhelmed: exploring health beliefs and barriers to oral anticancer medication adherence among cancer survivors.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
  8. Review
  9. Medication adherence in adults after hospitalization for heart failure: A cross-sectional study.International journal of cardiology. Cardiovascular risk and prevention · 2024
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Usefulness of a Nurse-Led Program of Care for Management of Patients with Chronic Heart Failure.Medical science monitor : international medical journal of experimental and clinical research · 2020
    Article
  15. Moving the Dial on Heart Failure Patient Adherence Rates.Patient preference and adherence · 2020
    Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jia-Rong WuSchool of Nursing, University of North Carolina at Chapel Hill, NC, United States. Electronic address: jiarongw@email.unc.edu.
Barbara MarkSchool of Nursing, University of North Carolina at Chapel Hill, NC, United States.
George J KnaflSchool of Nursing, University of North Carolina at Chapel Hill, NC, United States.
Sandra B DunbarSchool of Nursing, Emory University, Atlanta, GA, United States.
Patricia P ChangDivision of Cardiology, School of Medicine, University of North Carolina at Chapel Hill, NC, United States.
Darren A DeWaltDivision of General Medicine and Clinical Epidemiology, School of Medicine, University of North Carolina at Chapel Hill, NC, United States.

Funding

A Family-Focused, Literacy-Sensitive Intervention to Improve Medication AdherenceK23NR014489 · NINR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WU, JIA-RONG · 2013 to 2015
$379k
NINR NIH HHS K23 NR014489
6 · The paper itself

Abstract

backgroundMedication nonadherence is prevalent and links to serious outcomes (e.g., rehospitalization/death) in heart failure (HF) patients; therefore, an urgent need exists for an intervention to improve and sustain adherence after intervention completion.

objectivesTo test the efficacy of a multi-component, family-focused, literacy-sensitive (FamLit) intervention on medication adherence in HF patients.

methodsForty-three HF patients and their care partners were enrolled and randomized to receive FamLit or attention-only intervention, including an in-person session at baseline and bi-weekly phone boosters for 3 months. We measured medication adherence from baseline to 3-month post-intervention using the Medication Event Monitoring System.

resultsAfter 3-month intervention, intervention patients had significantly better medication adherence than control patients. At 6 months (3-months post-intervention), intervention effect on adherence was sustained in the FamLit intervention group, while adherence decreased in the control group.

conclusionIncorporating care partner support and providing an easy-to-understand intervention to patients-care partners may improve/sustain adherence.

Indexed as

CaregiversHealth LiteracyMedication AdherenceAgedFemaleHeart FailureHumansMaleMiddle AgedBehavior interventionFamily interventionHealth literacyMedication adherence

Identifiers

PMID31182217
PMCPMC6851458

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.