Evidence map›Paper›PMID 31182215›Full record

ArticleBiological psychiatry2019

Patterns of Psychiatric Comorbidity and Genetic Correlations Provide New Insights Into Differences Between Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder.

Berit S Solberg, Tetyana Zayats, Maj-Britt Posserud, Anne Halmøy, Anders Engeland, Jan Haavik, Kari Klungsøyr

Erratum issuedOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biological psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 33 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 6 pooled it
6.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 6 syntheses or guidelines pooled it, 63 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Guideline
  4. Pooled it
  5. Pooled it
  6. Pooled it
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  12. Genetic risk effects on psychiatric disorders act in sets.medRxiv : the preprint server for health sciences · 2025
    Article
  13. Article
  14. Alcohol Use Patterns Among Underage Autistic and Non-Autistic Youth.Journal of autism and developmental disorders · 2024
    Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Early childhood allergy linked with development of attention deficit hyperactivity disorder and autism spectrum disorder.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2022
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Berit S SolbergDepartment of Biomedicine, University of Bergen, Bergen, Norway; Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway; K.G. Jebsen Centre for Neuropsychiatric Disorders, University of Bergen, Bergen, Norway. Electronic address: bssol2004@yahoo.no.
Tetyana ZayatsDepartment of Biomedicine, University of Bergen, Bergen, Norway; K.G. Jebsen Centre for Neuropsychiatric Disorders, University of Bergen, Bergen, Norway; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts.
Maj-Britt PosserudK.G. Jebsen Centre for Neuropsychiatric Disorders, University of Bergen, Bergen, Norway; Department of Clinical Medicine, University of Bergen, Bergen, Norway; Department of Psychiatry, Haukeland University Hospital, Bergen, Norway.
Anne HalmøyDepartment of Biomedicine, University of Bergen, Bergen, Norway; K.G. Jebsen Centre for Neuropsychiatric Disorders, University of Bergen, Bergen, Norway; Department of Psychiatry, Haukeland University Hospital, Bergen, Norway.
Anders EngelandDepartment of Global Public Health and Primary Care, University of Bergen, Bergen, Norway; Division of Mental and Physical Health, Norwegian Institute of Public Health, Bergen, Norway.
Jan HaavikDepartment of Biomedicine, University of Bergen, Bergen, Norway; K.G. Jebsen Centre for Neuropsychiatric Disorders, University of Bergen, Bergen, Norway; Department of Psychiatry, Haukeland University Hospital, Bergen, Norway.
Kari KlungsøyrDepartment of Global Public Health and Primary Care, University of Bergen, Bergen, Norway; K.G. Jebsen Centre for Neuropsychiatric Disorders, University of Bergen, Bergen, Norway; Division of Mental and Physical Health, Norwegian Institute of Public Health, Bergen, Norway.
Haukeland University Hospital · NONorwegian Institute of Public Health · NOBroad Institute · USUniversity of Bergen · NO

Funding

2/7 Psychiatric Genomics Consortium: Finding Actionable VariationU01MH109539 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI DALY, MARK JOSEPH · 2016 to 2020
$4.7M
3/7 Psychiatric Genomics Consortium: Finding actionable variationU01MH109536 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CHARNEY, ALEXANDER W, HUCKINS, LAURA MARIANNE · 2016 to 2020
$2.7M
NIMH NIH HHS U01 MH109536NIMH NIH HHS U01 MH109539
6 · The paper itself

Abstract

backgroundAttention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) share common genetic factors but seem to have specific patterns of psychiatric comorbidities. There are few systematic studies on adults; therefore, we compared psychiatric comorbidities in adults with these two neurodevelopmental disorders using population-based data and analyzed their genetic correlations to evaluate underlying factors.

methodsUsing data from Norwegian registries, we assessed patterns of psychiatric disorders in adults with ADHD (n = 38,636; 2.3%), ASD (n = 7528; 0.4%), and both diagnoses (n = 1467; 0.1%) compared with the remaining adult population (n = 1,653,575). We calculated their prevalence ratios (PRs) and differences using Poisson regression, also examining sex-specific relations. Genetic correlations (r

resultsFor all psychiatric comorbidities, PRs differed between ADHD and ASD. Associations were strongest in individuals with ADHD and ADHD+ASD for most comorbidities, in both men and women. The relative prevalence increase of substance use disorder was three times larger in ADHD than in ASD (PR

conclusionsAdults with ADHD, ASD, or both ADHD and ASD have specific patterns of psychiatric comorbidities. This may partly be explained by differences in underlying genetic factors.

Indexed as

AdultAttention Deficit Disorder with HyperactivityAutism Spectrum DisorderComorbidityCross-Sectional StudiesFemaleHumansMaleMental DisordersNorwayRegistriesADHDASDGeneticsPsychiatric comorbiditySchizophreniaSUD

Identifiers

PMID31182215
PMCPMC6764861
OpenAlexW2940817615

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.