ArticleJournal of orthopaedic surgery and research2019
The impact of cholesterol deposits on the fibrillar architecture of the Achilles tendon in a rabbit model of hypercholesterolemia.
Article in Journal of orthopaedic surgery and research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 29 citations in OpenAlex.
- Skin keratin correlates with bone and tendon collagen quality: a proof-of-concept clinical study using FTIR spectroscopy in shoulder arthroplasty patients.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2026Article
- Transcriptional and post-translational mechanisms of ECM remodeling in rotator cuff tendons under hyperlipidemic conditions.Life sciences · 2025Article
- Understanding the impact of Achilles lipid content on tendon mechanical parameters: a cross-sectional study of people with familial hypercholesterolemia and healthy controls.BMC musculoskeletal disorders · 2025Article
- Outcomes of Rotator Cuff Repair: Open vs. Arthroscopic Approaches in Patients with Diabetes or Hyperlipidemia.Journal of orthopaedics and sports medicine · 2025Article
- Effect of Metabolic Syndrome in the incidence of Rotator Cuff Injury and Recovery following Surgical Repair.Journal of surgery and research · 2025Article
- Influence of statin use on progression of postoperative fatty infiltration in the arthroscopic rotator cuff repair.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2024Article
- Lipids, lipid-lowering drugs and lateral epicondylitis of the humerus: a drug-targeted Mendelian randomization study.Frontiers in genetics · 2024Article
- Effect of Aging on Tendon Biology, Biomechanics and Implications for Treatment Approaches.International journal of molecular sciences · 2023Review
- Corneal Wound Healing in the Presence of Antifibrotic Antibody Targeting Collagen Fibrillogenesis: A Pilot Study.International journal of molecular sciences · 2023Article
- Mild hypercholesterolemia impacts achilles sub-tendon mechanical properties in young rats.BMC musculoskeletal disorders · 2023Article
- Article
- Mouse Achilles tendons exhibit collagen disorganization but minimal collagen denaturation during cyclic loading to failure.Journal of biomechanics · 2023Article
- Exposure to oxLDL impairs TGF-β activity in human tendon cells.BMC musculoskeletal disorders · 2023Article
- Progress in studying the impact of hyperlipidemia and statins on rotator cuff injury and repair.Frontiers in public health · 2023Review
- Picrosirius-Polarization Method for Collagen Fiber Detection in Tendons: A Mini-Review.Orthopaedic surgery · 2021Review
- Mechanical properties of the different rotator cuff tendons in the rat are similarly and adversely affected by age.Journal of biomechanics · 2021Article
- Mechanisms of reducing joint stiffness by blocking collagen fibrillogenesis in a rabbit model of posttraumatic arthrofibrosis.PloS one · 2021Article
- The effects of cholesterol accumulation on Achilles tendon biomechanics: A cross-sectional study.PloS one · 2021Article
- Collagen-rich deposit formation in the sciatic nerve after injury and surgical repair: A study of collagen-producing cells in a rabbit model.Brain and behavior · 2020Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIncreased tendon pain and tendon damage is a significant complication related to hyperlipidemia. Unlike the well-established pathogenesis associated with increased serum concentrations of total cholesterol, triglycerides, and low-density lipoprotein in atherosclerotic cardiovascular disease, the role of hyperlipidemia in promoting tendon damage remains controversial and requires mechanistic clarity.
methodsIn this study, we analyzed the consequences of hypercholesterolemia on the integrity of the collagen-based architecture of the Achilles tendon. The Achilles tendons from rabbits fed with normal-cholesterol (nCH) and high-cholesterol (hCH) diets were analyzed. We studied the morphology of tendons, distribution of lipids within their collagen-rich milieu, the relative amounts of fibrillar collagen I and collagen III, and selected biomechanical parameters of the tendons at the macroscale and the nanoscale.
resultsHistological assays of hCH tendons and tenosynovium demonstrated hypercellular areas with increased numbers of macrophages infiltrating the tendon structure as compared to the nCH tendons. While Oil Red staining revealed lipid-rich deposits in the hCH tendons, hybridization of tendon tissue with the collagen hybridizing peptide (CHP) demonstrated damage to the collagen fibers. Fourier-transform infrared (FTIR) spectra showed the presence of distinct peaks consistent with the presence of cholesterol ester. Additionally, the hCH tendons displayed regions of poor collagen content that overlapped with lipid-rich regions. The hCH tendons had a substantial fourfold increase in the collage III to collagen I ratio as compared to the nCH tendons. Tendons from the hCH rabbits showed poor biomechanical characteristics in comparison with control. The biomechanical changes were evident at the macrolevel and the nanolevel of tendon structure.
conclusionsOur findings support the hypothesis that hypercholesterolemia coincides with the weakening of the tendons. It is likely that the intimate contact between collagen fibrils and cholesterol deposits contributes to the weakening of the fibrillar structure of the tendons.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.