ArticleRadiation oncology (London, England)2019
Ovarian transposition before radiotherapy in cervical cancer patients: functional outcome and the adequate dose constraint.
Article in Radiation oncology (London, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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16 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Outcomes of ovarian transposition in cervical cancer; an updated meta-analysis.BMC women's health · 2022Pooled it
- Role of anti-Müllerian hormone in predicting premature ovarian insufficiency after pelvic radiotherapy.Gynecologic oncology reports · 2026Article
- Preserved Menstruation After Chemoradiotherapy in Stage IIIC1 Cervical Cancer: A Unique Case.Journal of clinical medicine · 2026Article
- Ovarian dose prediction after ovarian transposition in cervical cancer: comparing three models and the impact of geometric distance on predictive performance.Frontiers in oncology · 2026Article
- Determination of ovarian transposition through prediction of postoperative adjuvant therapy in young patients with early stage cervical cancer undergoing surgery: a Korean multicenter retrospective study (KGOG 1042).Obstetrics & gynecology science · 2024Article
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- Fertility-sparing options for cancer patients.Abdominal radiology (New York) · 2023Review
- Preparation and Characterization Evaluation of Poly(L-Glutamic Acid)-International journal of nanomedicine · 2023Article
- Three-dimensional deep neural network for automatic delineation of cervical cancer in planning computed tomography images.Journal of applied clinical medical physics · 2022Article
- Perspectives of ERCC1 in early-stage and advanced cervical cancer: From experiments to clinical applications.Frontiers in immunology · 2022Review
- Significance of ovarian transposition in the preservation of ovarian function for young cervical cancer patients undergoing postoperative volumetric modulated radiotherapy.Annals of translational medicine · 2021Article
- Estimated radiation doses to ovarian and uterine organs in breast cancer irradiation using radio-photoluminescent glass dosimeters (RPLDs).Journal of medical radiation sciences · 2021Article
- Oncological Ligand-Target Binding Systems and Developmental Approaches for Cancer Theranostics.Molecular biotechnology · 2021Review
- Association between the location of transposed ovary and ovarian dose in patients with cervical cancer treated with postoperative pelvic radiotherapy.Radiation oncology (London, England) · 2019Article
- Ovarian Transposition Before Pelvic Radiation Therapy: Spatial Distribution and Dose Volume Analysis.Advances in radiation oncologyArticle
- Factors Associated With Premature Ovarian Insufficiency in Young Women With Locally Advanced Rectal Cancer Treated With Pelvic Radiation Therapy.Advances in radiation oncologyArticle
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5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe data regarding a transposed ovary in intensity-modulated radiotherapy (IMRT) are not sufficient. Here we aim to investigate the adequate dose constraint of ovarian transposition before radiotherapy in cervical cancer patients.
methodsThis was a retrospective analysis of 118 patients with cervical cancer who received a radical hysterectomy and ovarian transposition before pelvic irradiation from April 2012 to July 2017. A total of 105 patients underwent IMRT with a limited radiation dose to the ovaries; 48 of these patients received unilateral ovary limitation, while 57 received bilateral ovary limitations. Patient follow up regarding sex hormone levels (estrogen [E2], follicle stimulating hormone [FSH]) and menopausal symptoms was completed one year after their radiation therapy.
resultsA total of 41 out of 105 patients (39.0%) who underwent IMRT with a limited radiation dose to the ovaries preserved their normal ovarian function. The cutoff dose of comparatively lower side ovarian maximum dose was 9.985Gy and the cutoff of mean dose was 5.32Gy. The optimal dose-volume constrains to ovaries was V5.5 < 29.65%. Age ≤ 38 (P = 0.001) was an independent predictors of ovarian function, while limited ovarian side numbers were excluded.
conclusionUsing IMRT, preservation of ovarian function was possible when the limited dose was as low as possible to the ovaries regardless of bilateral or unilateral limitation to the ovaries. The ovarian maximum dose of less than 9.985Gy, the mean dose less than 5.32Gy and V5.5 < 29.65% could be better at preventing ovarian dysfunction. Patients younger than 38 years old were more likely to keep normal ovarian function while limited ovarian side numbers did not appear to exert an obvious effect.
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