ArticleRespiratory research2019
The Children's Respiratory and Environmental Workgroup (CREW) birth cohort consortium: design, methods, and study population.
Article in Respiratory research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 42 citations in OpenAlex.
- Longitudinal trajectories of severe wheeze exacerbations from infancy to school age and their association with early-life risk factors and late asthma outcomes.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2020Trial
- Genome-wide association study of asthma with high treatment burden and/or worse outcomes defined using electronic healthcare data in UK Biobank.ERJ open research · 2026Article
- Multicohort analysis unveils axon guidance pathways linking small for gestational age to spirometric restriction.Nature communications · 2026Article
- Redlining, Community Wealth, and Air Pollution: A Tale of Three Cities-Boston, Nashville, and Detroit.Journal of urban health : bulletin of the New York Academy of Medicine · 2026Article
- Individual and combined effects of indoor home exposures and ambient PMEnvironmental epidemiology (Philadelphia, Pa.) · 2026Article
- Predicting age of respiratory syncytial virus infection from birth timing.Nature communications · 2026Article
- Early-life wheeze trajectories are associated with distinct asthma transcriptomes later in life.The Journal of allergy and clinical immunology · 2025Article
- Genotypes in the 17q12-q21 asthma risk locus and early-life viral wheezing illnesses.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2025Article
- Genetic contributions to epigenetic-defined endotypes of allergic phenotypes in children.American journal of human genetics · 2025Article
- Phenotypes of Atopic Dermatitis and Development of Allergic Diseases.JAMA network open · 2025Observational
- Observational birth cohorts for causal and predictive inference: The example of childhood asthma and allergic diseases.The Journal of allergy and clinical immunology · 2025Review
- Integrating geospatial data with birth cohorts to explore social determinants of health and asthma.The Journal of allergy and clinical immunology · 2025Review
- The Legacy of Redlining: Increasing Childhood Asthma Disparities through Neighborhood Poverty.American journal of respiratory and critical care medicine · 2024Article
- Early-Life Exposure to Air Pollution and Childhood Asthma Cumulative Incidence in the ECHO CREW Consortium.JAMA network open · 2024Article
- How early life respiratory viral infections impact airway epithelial development and may lead to asthma.Frontiers in pediatrics · 2024Review
- Short Report: Exploring the Effect of Prenatal Fatty Acid Supplementation on Wheeze and Asthma in Black American Children.Journal of asthma and allergy · 2024Article
- Performance of the Pediatric Asthma Risk Score across Diverse Populations.NEJM evidence · 2023Article
- Defining and Promoting Pediatric Pulmonary Health: Assessing Lung Function and Structure.Pediatrics · 2023Article
- African-specific alleles modify risk for asthma at the 17q12-q21 locus in African Americans.Genome medicine · 2022Article
- Heritable vaginal bacteria influence immune tolerance and relate to early-life markers of allergic sensitization in infancy.Cell reports. Medicine · 2022Article
Corrections and comments
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Authors and funding
26 authors at 14 institutions in 1 country.
Funding
Abstract
backgroundSingle birth cohort studies have been the basis for many discoveries about early life risk factors for childhood asthma but are limited in scope by sample size and characteristics of the local environment and population. The Children's Respiratory and Environmental Workgroup (CREW) was established to integrate multiple established asthma birth cohorts and to investigate asthma phenotypes and associated causal pathways (endotypes), focusing on how they are influenced by interactions between genetics, lifestyle, and environmental exposures during the prenatal period and early childhood. METHODS AND
resultsCREW is funded by the NIH Environmental influences on Child Health Outcomes (ECHO) program, and consists of 12 individual cohorts and three additional scientific centers. The CREW study population is diverse in terms of race, ethnicity, geographical distribution, and year of recruitment. We hypothesize that there are phenotypes in childhood asthma that differ based on clinical characteristics and underlying molecular mechanisms. Furthermore, we propose that asthma endotypes and their defining biomarkers can be identified based on personal and early life environmental risk factors. CREW has three phases: 1) to pool and harmonize existing data from each cohort, 2) to collect new data using standardized procedures, and 3) to enroll new families during the prenatal period to supplement and enrich extant data and enable unified systems approaches for identifying asthma phenotypes and endotypes.
conclusionsThe overall goal of CREW program is to develop a better understanding of how early life environmental exposures and host factors interact to promote the development of specific asthma endotypes.
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Registered trials
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