Evidence map›Paper›PMID 31182072›Full record

ArticleRespiratory research2019

Single-photon emission computed tomography/computed tomography imaging of RAGE in smoking-induced lung injury.

Monica P Goldklang, Yared Tekabe, Tina Zelonina, Jordis Trischler, Rui Xiao, Kyle Stearns, Krissy Rodriguez, Alexander Shields, Alexander Romanov, Jeanine M D'Armiento and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Progress of RAGE Molecular Imaging in Alzheimer's Disease.Frontiers in aging neuroscience · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Monica P GoldklangDepartment of Anesthesiology, Columbia University, New York, NY, USA.
Yared TekabeDepartment of Medicine, Columbia University, New York, NY, USA.
Tina ZeloninaDepartment of Anesthesiology, Columbia University, New York, NY, USA.
Jordis TrischlerDepartment of Anesthesiology, Columbia University, New York, NY, USA.
Rui XiaoDepartment of Anesthesiology, Columbia University, New York, NY, USA.
Kyle StearnsDepartment of Anesthesiology, Columbia University, New York, NY, USA.
Krissy RodriguezDepartment of Medicine, Columbia University, New York, NY, USA.
Alexander ShieldsDepartment of Anesthesiology, Columbia University, New York, NY, USA.
Alexander RomanovInstitute for Comparative Medicine, Columbia University, New York, NY, USA.
Jeanine M D'ArmientoDepartment of Anesthesiology, Columbia University, New York, NY, USA. jmd12@cumc.columbia.edu.ORCID http://orcid.org/0000-0002-6219-6083
Lynne L JohnsonDepartment of Medicine, Columbia University, New York, NY, USA. lj2129@cumc.columbia.edu.
Columbia University · USColumbia University Irving Medical Center · US

Funding

True Metal fac coreP30ES009089 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MATTHEW S PERZANOWSKI · 1998 to 2026
$44.7M
Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2M
POSTDOCTORAL TRAINING IN ARTERIOSCLEROSIS RESEARCHT32HL007343 · NHLBI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI HENRY N GINSBERG, Muredach P Reilly · 1985 to 2026
$12.7M
Smoke Induced Airway Injury in the LungR01HL086936 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI D'ARMIENTO, JEANINE M · 2007 to 2016
$3.7M
Summer Program for Under Represented Students (SPURS)R25NS076445 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Wesley B Grueber, STEVEN A SIEGELBAUM · 2012 to 2026
$1.4M
Imaging RAGE Pro-inflammatory Signaling and Cellular Apoptosis in EmphysemaR01HL116346 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI D'ARMIENTO, JEANINE M, JOHNSON, LYNNE L. · 2012 to 2014
$1.1M
Smoke induced alterations in ion channel functionK08HL126071 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GOLDKLANG, MONICA PRASAD · 2015 to 2019
$788k
NCATS NIH HHS U01 TR000040NCATS NIH HHS UL1 TR000040NHLBI NIH HHS K08 HL126071NHLBI NIH HHS R01 HL086936NHLBI NIH HHS R01 HL116346NHLBI NIH HHS T32 HL007343NIEHS NIH HHS P30 ES009089NINDS NIH HHS R25 NS076445
6 · The paper itself

Abstract

backgroundExpression of the Receptor for Advanced Glycation Endproducts (RAGE) initiates pro-inflammatory pathways resulting in lung destruction. We hypothesized that RAGE directed imaging demonstrates increased lung uptake in smoke-exposure.

methodsAfter exposure to room air or to cigarette smoke for 4-weeks or 16-weeks, rabbits were injected with

results

conclusionsRAGE-directed imaging identified pulmonary RAGE expression acutely in vivo in an animal model of emphysema early after smoke exposure, with diminution over time. These studies document the extent and time course of RAGE expression under smoke exposure conditions and could be utilized for disease monitoring and examining response to future RAGE-targeted therapies.

Indexed as

Disease Models, AnimalAnimalsFemaleLungRabbitsReceptor for Advanced Glycation End ProductsSingle Photon Emission Computed Tomography Computed TomographySmokingTobacco SmokingReceptor for Advanced Glycation End ProductsCigarette smokeDamage-associated molecular patternEmphysemaHGMB1ImagingRabbitReceptor for advanced glycation end products

Identifiers

PMID31182072
PMCPMC6558785
OpenAlexW2952860162

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.