ArticleBMC cancer2019
Polygenic prediction of breast cancer: comparison of genetic predictors and implications for risk stratification.
Article in BMC cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- A systematic review of prediction models for risk of breast cancer.BMC cancer · 2025Pooled it
- Polygenic scores in Familial breast cancer cases with and without pathogenic variants and the risk of contralateral breast cancer.Breast cancer research : BCR · 2025Article
- The Estonian Biobank's journey from biobanking to personalized medicine.Nature communications · 2025Review
- Enhanced fracture risk prediction: a novel multi-trait genetic approach integrating polygenic scores of fracture-related traits.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2024Article
- Comprehensive Inherited Risk Estimation for Risk-Based Breast Cancer Screening in Women.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2024Article
- Polygenic risk scores for cervical HPV infection, neoplasia and cancer show potential for personalised screening: comparison of two methods.Infectious agents and cancer · 2023Article
- Review
- Clinical utility of polygenic risk scores: a critical 2023 appraisal.Journal of community genetics · 2023Article
- A Breast Cancer Polygenic Risk Score Is Feasible for Risk Stratification in the Norwegian Population.Cancers · 2023Article
- Development of Competency-based Online Genomic Medicine Training (COGENT).Personalized medicine · 2023Review
- Assessing agreement between different polygenic risk scores in the UK Biobank.Scientific reports · 2022Article
- Induced mammary cancer in rat models: pathogenesis, genetics, and relevance to female breast cancer.Journal of mammary gland biology and neoplasia · 2022Review
- Article
- Questioning the validity of clinically available breast cancer polygenic risk scores: comparison of two labs reveals discrepancies.Familial cancer · 2022Article
- A Principal Component Informed Approach to Address Polygenic Risk Score Transferability Across European Cohorts.Frontiers in genetics · 2022Article
- Evaluating the prognostic performance of a polygenic risk score for breast cancer risk stratification.BMC cancer · 2021Article
- Review
- DAGM: A novel modelling framework to assess the risk of HER2-negative breast cancer based on germline rare coding mutations.EBioMedicine · 2021Article
- Advances in Genomic Discovery and Implications for Personalized Prevention and Medicine: Estonia as Example.Journal of personalized medicine · 2021Review
- Simplified Breast Risk Tool Integrating Questionnaire Risk Factors, Mammographic Density, and Polygenic Risk Score: Development and Validation.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundPublished genetic risk scores for breast cancer (BC) so far have been based on a relatively small number of markers and are not necessarily using the full potential of large-scale Genome-Wide Association Studies. This study aimed to identify an efficient polygenic predictor for BC based on best available evidence and to assess its potential for personalized risk prediction and screening strategies.
methodsFour different genetic risk scores (two already published and two newly developed) and their combinations (metaGRS) were compared in the subsets of two population-based biobank cohorts: the UK Biobank (UKBB, 3157 BC cases, 43,827 controls) and Estonian Biobank (EstBB, 317 prevalent and 308 incident BC cases in 32,557 women). In addition, correlations between different genetic risk scores and their associations with BC risk factors were studied in both cohorts.
resultsThe metaGRS that combines two genetic risk scores (metaGRS
conclusionsWe have shown that metaGRS
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.