ArticleBMC bioinformatics2019
Dynamic genome-scale cell-specific metabolic models reveal novel inter-cellular and intra-cellular metabolic communications during ovarian follicle development.
Article in BMC bioinformatics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 25 citations in OpenAlex.
- Cross-species metabolic profiling of follicular compartments in obesity.Life medicine · 2026Article
- A Novel Network Approach to Identify Sample-Specific Context-Informed Metabolic Signatures During Developmental Processes.bioRxiv : the preprint server for biology · 2026Article
- Multi-omics reveal the metabolic patterns in mouse cumulus cells during oocyte maturation.Journal of ovarian research · 2023Article
- Nitric oxide synthase and its function in animal reproduction: an update.Frontiers in physiology · 2023Review
- Successful 3D culture and transplantation of mouse isolated preantral follicles in hydrogel of bioengineered Wharton's jelly.PloS one · 2023Article
- Metabolic Control of Germline Formation and Differentiation in Mammals.Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation · 2022Review
- Correlation between Pre-Ovulatory Follicle Diameter and Follicular Fluid Metabolome Profiles in Lactating Beef Cows.Metabolites · 2021Article
- Capitalizing on transcriptome profiling to optimize and identify targets for promoting early murine folliculogenesis in vitro.Scientific reports · 2021Article
- Clavulanic Acid Production byAntibiotics (Basel, Switzerland) · 2021Review
- Hypothalamic Transcriptome Analysis Reveals the Crucial MicroRNAs and mRNAs Affecting Litter Size in Goats.Frontiers in veterinary science · 2021Article
- Ligands, Receptors, and Transcription Factors that Mediate Inter-Cellular and Intra-Cellular Communication during Ovarian Follicle Development.Reproductive sciences (Thousand Oaks, Calif.) · 2020Article
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundThe maturation of the female germ cell, the oocyte, requires the synthesis and storing of all the necessary metabolites to support multiple divisions after fertilization. Oocyte maturation is only possible in the presence of surrounding, diverse, and changing layers of somatic cells. Our understanding of metabolic interactions between the oocyte and somatic cells has been limited due to dynamic nature of ovarian follicle development, thus warranting a systems approach.
resultsHere, we developed a genome-scale metabolic model of the mouse ovarian follicle. This model was constructed using an updated mouse general metabolic model (Mouse Recon 2) and contains several key ovarian follicle development metabolic pathways. We used this model to characterize the changes in the metabolism of each follicular cell type (i.e., oocyte, granulosa cells, including cumulus and mural cells), during ovarian follicle development in vivo. Using this model, we predicted major metabolic pathways that are differentially active across multiple follicle stages. We identified a set of possible secreted and consumed metabolites that could potentially serve as biomarkers for monitoring follicle development, as well as metabolites for addition to in vitro culture media that support the growth and maturation of primordial follicles.
conclusionsOur systems approach to model follicle metabolism can guide future experimental studies to validate the model results and improve oocyte maturation approaches and support growth of primordial follicles in vitro.
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