Evidence map›Paper›PMID 31181961›Full record

ArticleAIDS care2020

Predictors of isoniazid preventive therapy completion among HIV-infected patients receiving differentiated and non-differentiated HIV care in rural Uganda.

Khai Hoan Tram, Florence Mwangwa, Gabriel Chamie, Mucunguzi Atukunda, Asiphas Owaraganise, James Ayieko, Vivek Jain, Tamara D Clark, Dalsone Kwarisiima, Maya L Petersen and 5 more

Registry-linked trialAbstract read
In one paragraph

Article in AIDS care, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01864603 (Sustainable East Africa Research in Community Health), which is not on this map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01864603 nacompletednot on this map

Sustainable East Africa Research in Community Health

TypeinterventionalSponsorUniversity of California, San FranciscoRan2013 to 2021Enrolled150,395ConditionsHIV, Tuberculosis, Hypertension, DiabetesArmsUniversal ART in a streamlined care model, Annual Community Health Campaigns, Targeted PrEP and Targeted testing interventions, Baseline community-based HIV and multi-disease testing
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Khai Hoan TramSchool of Medicine, Stanford University, Stanford, CA, USA.
Florence MwangwaInfectious Diseases Research Collaboration, Kampala, Uganda.
Gabriel ChamieDivision of HIV, Infectious Diseases and Global Medicine, University of California, San Francisco, CA, USA.
Mucunguzi AtukundaInfectious Diseases Research Collaboration, Kampala, Uganda.
Asiphas OwaraganiseInfectious Diseases Research Collaboration, Kampala, Uganda.
James AyiekoKenya Medical Research Institute, Nairobi, Kenya.
Vivek JainDivision of HIV, Infectious Diseases and Global Medicine, University of California, San Francisco, CA, USA.
Tamara D ClarkDivision of HIV, Infectious Diseases and Global Medicine, University of California, San Francisco, CA, USA.
Dalsone KwarisiimaInfectious Diseases Research Collaboration, Kampala, Uganda.
Maya L PetersenSchool of Medicine, Makerere University College of Health Sciences, Kampala, Uganda.
Moses R KamyaInfectious Diseases Research Collaboration, Kampala, Uganda.
Edwin D CharleboisDivision of HIV, Infectious Diseases and Global Medicine, University of California, San Francisco, CA, USA.
Diane V HavlirDivision of HIV, Infectious Diseases and Global Medicine, University of California, San Francisco, CA, USA.
Carina MarquezDivision of HIV, Infectious Diseases and Global Medicine, University of California, San Francisco, CA, USA.
SEARCH collaborationSchool of Medicine, Stanford University, Stanford, CA, USA.

Funding

Ujima Mentoring ProgramP30MH062246 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MALLORY O JOHNSON · 2001 to 2026
$57.4M
Reducing Failure-to-Initiate ART: Streamlined ART Start Strategy (START)U01AI099959 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HAVLIR, DIANE V · 2012 to 2016
$39.7M
San Francisco Vaccine and Prevention UnitUM1AI069496 · NIAID · PUBLIC HEALTH FOUNDATION ENTERPRISES · PI Susan Buchbinder, Diane V Havlir · 2012 to 2026
$30.5M
Childhood Tuberculosis Infection Among School-Age Children in Rural UgandaK23AI118592 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MARQUEZ, CARINA · 2015 to 2019
$946k
NIAID NIH HHS K23 AI118592NIAID NIH HHS U01 AI099959NIAID NIH HHS UM1 AI069496NIMH NIH HHS P30 MH062246PEPFAR
6 · The paper itself

Abstract

Rates of Isoniazid Preventive Therapy (IPT) completion remain low in programmatic settings in sub-Saharan Africa. Differentiated HIV care models may improve IPT completion by addressing joint barriers to IPT and HIV treatment. However, the impact of differentiated care on IPT completion remains unknown. In a cross-sectional study of people with HIV on antiretroviral therapy in 5 communities in rural Uganda, we compared IPT completion between patients receiving HIV care via a differentiated care model versus a standard HIV care model and assessed multi-level predictors of IPT completion. A total of 103/144 (72%) patients received differentiated care and 85/161 (53%) received standard care completed IPT (

Indexed as

Rural PopulationAdultAnti-HIV AgentsAntitubercular AgentsCross-Sectional StudiesFemaleHIV InfectionsHumansIsoniazidMaleMiddle AgedTuberculosisUgandaAnti-HIV AgentsAntitubercular AgentsIsoniaziddifferentiated careEast AfricaHIVIsoniazid preventive therapyTB prevention

Identifiers

PMID31181961
PMCPMC6883160

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.