Evidence map›Paper›PMID 31181711›Full record

ArticleGenes2019

Detection of Transgenes in Gene Delivery Model Mice by Adenoviral Vector Using ddPCR.

Takehito Sugasawa, Kai Aoki, Koichi Watanabe, Koki Yanazawa, Tohru Natsume, Tohru Takemasa, Kaori Yamaguchi, Yoshinori Takeuchi, Yuichi Aita, Naoya Yahagi and 8 more

Open access · goldAbstract read
In one paragraph

Article in Genes, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. [Gene doping: current test methods and analytical challenges].Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 3 institutions in 1 country.

Takehito SugasawaLaboratory of Laboratory/Sports medicine, Division of Clinical Medicine, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Ibaraki 305-8577, Japan. take0716@krf.biglobe.ne.jp.
Kai AokiGraduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba 305-8577, Japan. fineday0126@gmail.com.
Koichi WatanabeFaculty of Health and Sport Sciences, University of Tsukuba, Tsukuba 305-8577, Japan. watanabe.koichi.ga@u.tsukuba.ac.jp.
Koki YanazawaGraduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba 305-8577, Japan. s1921312@s.tsukuba.ac.jp.
Tohru NatsumeMolecular Profiling Research Center for Drug Discovery, National Institute of Advanced Industrial Science and Technology (AIST), Tokyo 100-8921, Japan. t-natsume@aist.go.jp.
Tohru TakemasaFaculty of Health and Sport Sciences, University of Tsukuba, Tsukuba 305-8577, Japan. takemasa.tohru.gm@u.tsukuba.ac.jp.ORCID 0000-0002-9591-2250
Kaori YamaguchiFaculty of Health and Sport Sciences, University of Tsukuba, Tsukuba 305-8577, Japan. yamaguchi.kaori.gf@u.tsukuba.ac.jp.
Yoshinori TakeuchiNutrigenomics Research Group, Faculty of Medicine, University of Tsukuba, Ibaraki 305-8575, Japan. yoshinori-takeuchi@umin.ac.jp.
Yuichi AitaNutrigenomics Research Group, Faculty of Medicine, University of Tsukuba, Ibaraki 305-8575, Japan. metabmetabmetab@gmail.com.
Naoya YahagiNutrigenomics Research Group, Faculty of Medicine, University of Tsukuba, Ibaraki 305-8575, Japan. nyahagi-tky@umin.ac.jp.
Yasuko YoshidaDepartment of Medical Technology, Faculty of Health Sciences, Tsukuba International University, 6-20-1 Manabe, Tsuchiura, Ibaraki 300-0051, Japan. shinbelon@mwa.biglobe.ne.jp.
Katsuyuki TokinoyaGraduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba 305-8577, Japan. ilbsk5@yahoo.co.jp.
Nanami SekineGraduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba 305-8577, Japan. s1721298@s.tsukuba.ac.jp.
Kaoru TakeuchiLaboratory of Environmental Microbiology, Division of Basic Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba 305-8575, Japan. ktakeuch@md.tsukuba.ac.jp.
Haruna UedaGraduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba 305-8577, Japan. s1821255@s.tsukuba.ac.jp.
Yasushi KawakamiLaboratory of Laboratory/Sports medicine, Division of Clinical Medicine, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Ibaraki 305-8577, Japan. y-kawa@md.tsukuba.ac.jp.
Satoshi ShimizuFaculty of Health and Sport Sciences, University of Tsukuba, Tsukuba 305-8577, Japan. shimizu.satoshi.fe@u.tsukuba.ac.jp.
Kazuhiro TakekoshiLaboratory of Laboratory/Sports medicine, Division of Clinical Medicine, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Ibaraki 305-8577, Japan. k-takemd@md.tsukuba.ac.jp.
University of Tsukuba · JPNational Institute of Advanced Industrial Science and Technology · JPTsukuba International University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

With the rapid progress of genetic engineering and gene therapy, the World Anti-Doping Agency has been alerted to gene doping and prohibited its use in sports. However, there is no standard method available yet for the detection of transgenes delivered by recombinant adenoviral (rAdV) vectors. Here, we aim to develop a detection method for transgenes delivered by rAdV vectors in a mouse model that mimics gene doping. These rAdV vectors containing the

Indexed as

Doping in SportsAdenoviridaeAnimalsGenetic TherapyGenetic VectorsGene Transfer TechniquesHumansMiceTransgenesadenoviral vectordroplet digital PCRgene dopinggene therapy

Identifiers

PMID31181711
PMCPMC6627169
OpenAlexW2947163565

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.