Evidence map›Paper›PMID 31181621›Full record

ReviewNutrients2019

Boosting GSH Using the Co-Drug Approach: I-152, a Conjugate of

Rita Crinelli, Carolina Zara, Michaël Smietana, Michele Retini, Mauro Magnani, Alessandra Fraternale

Open access · goldAbstract readReview
In one paragraph

Review in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.3field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. The Role of Glutathione in Selected Viral Diseases.Antioxidants (Basel, Switzerland) · 2023
    Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Redox-Modulating Agents in the Treatment of Viral Infections.International journal of molecular sciences · 2020
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Rita CrinelliDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, 61029 Urbino, Italy. rita.crinelli@uniurb.it.
Carolina ZaraDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, 61029 Urbino, Italy. c.zara@campus.uniurb.it.
Michaël SmietanaInstitut des Biomolécules Max Mousseron, Université de Montpellier UMR 5247 CNRS, ENSCM, 34095 Montpellier, France. michael.smietana@umontpellier.fr.ORCID 0000-0001-8132-7221
Michele RetiniDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, 61029 Urbino, Italy. michele.retini@uniurb.it.ORCID 0000-0003-0218-8505
Mauro MagnaniDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, 61029 Urbino, Italy. mauro.magnani@uniurb.it.ORCID 0000-0001-6456-6626
Alessandra FraternaleDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, 61029 Urbino, Italy. alessandra.fraternale@uniurb.it.
University of Urbino · ITÉcole Nationale Supérieure de Chimie de Montpellier · FR

Funding

Ministero dell'Istruzione, dell'Università e della Ricerca PRIN [Research Projects of National Interest] 2010-2011-prot. 2010PHT9NF_004
6 · The paper itself

Abstract

Glutathione (GSH) has poor pharmacokinetic properties; thus, several derivatives and biosynthetic precursors have been proposed as GSH-boosting drugs. I-152 is a conjugate of

Indexed as

AcetylcysteineAnimalsAntiviral AgentsCysteamineGlutathioneHumansImmunologic FactorsProdrugsRetroviridaeSulfhydryl CompoundsVirus DiseasesAcetylcysteineAntiviral AgentsCysteamineGlutathioneImmunologic FactorsProdrugsSulfhydryl Compoundsantiviral activityco-drugcysteamineglutathioneimmunomodulationN-acetyl-cysteinepro-glutathione molecules

Identifiers

PMID31181621
PMCPMC6627109
OpenAlexW2948616961

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.