Observational studyAtherosclerosis2019
Subjects with diffuse idiopathic skeletal hyperostosis have an increased burden of coronary artery disease: An evaluation in the COPDGene cohort.
Observational study in Atherosclerosis, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- The relation between cardiovascular calcifications and diffuse idiopathic skeletal hyperostosis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Review
- Association of Arterial Hypertension with Thoracic Spondylophyte Formation: A Secondary Analysis of Cross-Sectional MRI Data from the SHIP Cohort.Healthcare (Basel, Switzerland) · 2026Article
- Association between body roundness index and the prevalence of diffuse idiopathic skeletal hyperostosis in elderly patients: the Bunkyo health study.Scientific reports · 2026Article
- DISH as a marker for incident diabetes mellitus in cardiovascular disease patients.Rheumatology (Oxford, England) · 2025Article
- Prevalence of diffuse idiopathic skeletal hyperostosis and association with coronary artery calcifications in Slovenia.Radiology and oncology · 2025Article
- Spatiotemporal changes in imaging features associated with diffuse idiopathic skeletal hyperostosis (DISH).RMD open · 2024Article
- Osteophyte Bridge Formation Correlates with Vascular Calcification and Cardiovascular Disease in Diffuse Idiopathic Skeletal Hyperostosis.Journal of clinical medicine · 2023Article
- Prevalence and characteristics of diffuse idiopathic skeletal hyperostosis (DISH) in Italy.La Radiologia medica · 2022Article
- Incidence and Predictive Factors of Massive Hemothorax Due to Thoracic Vertebral Fractures.Spine surgery and related research · 2022Article
- Diffuse idiopathic skeletal hyperostosis is associated with incident stroke in patients with increased cardiovascular risk.Rheumatology (Oxford, England) · 2022Article
- The Prevalence and Characteristics of Diffuse Idiopathic Skeletal Hyperostosis (DISH): A Cross-Sectional Study of 1519 Japanese Individuals.Diagnostics (Basel, Switzerland) · 2022Article
- Immune cell infiltration and the genes associated with ligamentum flavum hypertrophy: Identification and validation.Frontiers in cell and developmental biology · 2022Article
- Patients with diffuse idiopathic skeletal hyperostosis have an increased burden of thoracic aortic calcifications.Rheumatology advances in practice · 2022Article
- Pseudohypoparathyroidism mimicking cervical diffuse idiopathic skeletal hyperostosis with dysphagia: A case report and literature review.Bone reports · 2021Article
- Association between diffuse idiopathic skeletal hyperostosis and thoracic kyphosis in patients with cervical myelopathy: a retrospective observational study.BMC musculoskeletal disorders · 2021Observational
- Mammograms to catch many birds with one stone.European heart journal · 2021Article
- Cardiovascular disease in diffuse idiopathic skeletal hyperostosis (DISH): from theory to reality-a 10-year follow-up study.Arthritis research & therapy · 2020Article
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 2 countries.
Funding
Abstract
BACKGROUND AND
aimsDiffuse idiopathic skeletal hyperostosis (DISH) is a common incidental finding on medical imaging and often thought to be benign. Our objective was to investigate whether DISH is associated with coronary artery disease as measured with the coronary artery calcification (CAC) score in a large cohort of current and former smokers.
methodsIn a subset of subjects from the COPDGene study, DISH was scored by a minimum of two independent readers if there were four adjacent levels of flowing osteophytes and a third reader adjudicated discrepancies. CAC was calculated using a modified Agatston method. Associations of DISH with the presence and extent of CAC were analyzed with and without adjustment for COPD and known atherosclerotic risk factors, including age, sex, race, diabetes, hypertension, high cholesterol, body mass index and smoking.
resultsDISH was present in 361 subjects (13.2%) from a total group of 2728. Median (interquartile range) Agatston was 81 (0-329) in DISH subjects compared to 0 (0-94 in subjects without DISH (p < 0.001). DISH prevalence was 8.8% in CAC = 0, 12.8% in CAC1-100, 20.0% in CAC100-400 and 24.7% in CAC.400. Subjects with DISH had a significantly higher risk of having coronary artery calcifications; OR [CI95%] 1.37[1.05-1.78] (p=0.019) after correction for age, gender, race, COPD and atherosclerotic risk factors.
conclusionsSubjects with DISH, a common musculoskeletal disorder involving bone formation anterior to the spine, have an increased burden of coronary artery disease, and therefore DISH may be a more relevant incidental finding than commonly thought.
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