Evidence map›Paper›PMID 31181288›Full record

ArticleJournal of molecular biology2019

The Cytoplasm-Entry Domain of Antibacterial CdiA Is a Dynamic α-Helical Bundle with Disulfide-Dependent Structural Features.

Nicholas L Bartelli, Sheng Sun, Grant C Gucinski, Hongjun Zhou, Kiho Song, Christopher S Hayes, Frederick W Dahlquist

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of molecular biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nicholas L BartelliDepartment of Chemistry and Biochemistry, University of California, Santa Barbara, CA 93106, United States.
Sheng SunDepartment of Chemistry and Biochemistry, University of California, Santa Barbara, CA 93106, United States.
Grant C GucinskiDepartment of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, CA 93106, United States.
Hongjun ZhouDepartment of Chemistry and Biochemistry, University of California, Santa Barbara, CA 93106, United States.
Kiho SongBiomolecular Science and Engineering Program, University of California, Santa Barbara, CA 93106, United States.
Christopher S HayesDepartment of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, CA 93106, United States; Biomolecular Science and Engineering Program, University of California, Santa Barbara, CA 93106, United States. Electronic address: chayes@lifesci.ucsb.edu.
Frederick W DahlquistDepartment of Chemistry and Biochemistry, University of California, Santa Barbara, CA 93106, United States; Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, CA 93106, United States; Biomolecular Science and Engineering Program, University of California, Santa Barbara, CA 93106, United States. Electronic address: dahlquist@ucsb.edu.

Funding

MECHANISTIC STUDIES OF BACTERIAL CHEMOTAXISR01GM059544 · NIGMS · UNIVERSITY OF OREGON · PI DAHLQUIST, FREDERICK W. · 1999 to 2018
$4.8M
Molecular Mechanisms of anti-bacterial contact-dependent growth inhibition (CDI)R01GM117930 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI HAYES, CHRISTOPHER S. · 2016 to 2023
$3.0M
Specificity Determinants of Contact Dependent InhibitionR21AI121789 · NIAID · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI DAHLQUIST, FREDERICK W. · 2016 to 2017
$386k
NIAID NIH HHS R21 AI121789NIGMS NIH HHS R01 GM059544NIGMS NIH HHS R01 GM117930
6 · The paper itself

Abstract

Many Gram-negative bacterial species use contact-dependent growth inhibition (CDI) systems to compete with neighboring cells. CDI

Indexed as

Protein DomainsAmino Acid SequenceAnti-Bacterial AgentsBacterial ToxinsContact InhibitionCrystallography, X-RayCysteineCytoplasmDisulfidesEscherichia coliEscherichia coli ProteinsMembrane ProteinsProtein Conformation, alpha-HelicalProtein Structure, SecondaryProtein TransportType V Secretion SystemsAnti-Bacterial AgentsBacterial ToxinsCdiA protein, E coliCysteineDisulfidesEscherichia coli ProteinsMembrane ProteinsType V Secretion Systemsbacterial competitionBamAtwo-partner secretiontype V secretion system

Identifiers

PMID31181288
PMCPMC6727969

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.