ArticlePsychosomatic medicine2019
Grief: A Brief History of Research on How Body, Mind, and Brain Adapt.
Article in Psychosomatic medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 104 citations in OpenAlex.
- Effectiveness of grief interventions in underrepresented regions: a systematic review and exploratory meta-analysis.European journal of psychotraumatology · 2026Pooled it
- Grief-Related Chest Pain: A Review, Conceptual Analysis, and Integrative Model.Psychophysiology · 2026Pooled it
- Risk for Complicated Grief After the COVID-19 Death of a Marital Partner in Late Life.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2024Trial
- Autonomic evidence that avoidance matters in the mourning process: A prospective observational study in Japan.Dialogues in clinical neuroscience · 2026Observational
- Bereavement and Risk of Cardiovascular Disease Before and During the COVID-19 Pandemic.JAMA network open · 2026Article
- The Range of Response to Loss: an innovative theory of grief and a framework for use in practice and research.Frontiers in psychology · 2026Article
- Patterns of Physical Activity and Depressive Symptoms Among Korean Adults: A Descriptive Cross-Sectional Analysis of the 2023 Korea Community Health Survey.Healthcare (Basel, Switzerland) · 2025Article
- Instruments for measuring grief in bereaved adults: a protocol for a COSMIN-based systematic review.BMJ open · 2025Article
- Quality of life and widowhood: a cross-sectional study of social security scheme beneficiaries.BMC public health · 2025Article
- Associations between positive and negative social experiences and epigenetic aging.Scientific reports · 2025Article
- Territories of mourning: Addressing submerged problems of grief through multidisciplinary care.World journal of clinical cases · 2025Article
- Mindfulness and Relaxation Interventions Reduce Depression, Negative Affect and Stress in Widow(er)s.Journal of loss & trauma · 2025Article
- Loss and Grief in Parents of Children Hospitalized for Congenital Heart Disease.Hospital pediatrics · 2025Article
- Supporting the bereaved child in the adult ICU: a narrative review.Intensive care medicine · 2025Review
- Prevalence of bereavement among current smokers in a state-wide cross-sectional surveillance survey.Tobacco induced diseases · 2025Article
- Searching for the unexpected - understanding information-seeking behaviours of people new to prison visits.Psychiatry, psychology, and law : an interdisciplinary journal of the Australian and New Zealand Association of Psychiatry, Psychology and Law · 2025Article
- Prolonged Grief Disorder: Unveiling Neurobiological Mechanisms for a Shared Path Forward.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2024Article
- Neural correlates of deceased-related attention during acute grief in suicide-related bereavement.Journal of affective disorders · 2024Article
- The nature of grief: implications for the neurobiology of emotion.Neuroscience of consciousness · 2024Article
- Somatic symptoms and insomnia among bereaved parents and siblings eight years after the Utøya terror attack.European journal of psychotraumatology · 2024Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
objectiveUsing an integrative view of psychology, neuroscience, immunology, and psychophysiology, the present review of literature curates the findings that have had an impact on the field of bereavement research and shaped its development.
methodsBeginning with pivotal systematic descriptions of medical and psychological responses to the death of a loved one by Lindemann in the mid-1940s, this selective review integrates findings in bereavement research from studies that investigate medical outcomes after loss, their psychological predictors, and biopsychosocial mechanisms.
resultsMorbidity and mortality after the death of a loved one have long been a topic of research. Early researchers characterized somatic and psychological symptoms and studied immune cell changes in bereaved samples. More recent research has repeatedly demonstrated increased rates of morbidity and mortality in bereaved samples, as compared with married controls, in large epidemiological studies. Recent developments also include the development of criteria for prolonged grief disorder (also termed complicated grief). Newer methods, including neuroimaging, have observed that the greatest impact of the death of a loved one is in those who have the most severe psychological grief reactions. Research addressing the mechanisms tying bereavement to medical outcomes is relatively scarce, but differences in rumination, in inflammation, and in cortisol dysregulation between those who adapt well and those who do not have been offered with some evidence.
conclusionsRecommendations to propel the field forward include longitudinal studies to understand differences between acute reactions and later adaptation, comparing samples with grief disorders from those with more typical responses, and integrating responses in brain, mind, and body.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.