ArticleEpidemiology (Cambridge, Mass.)2019
Polybrominated Biphenyl Exposure and Menstrual Cycle Function.
Article in Epidemiology (Cambridge, Mass.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Persistent organic pollutants and couple fecundability: a systematic review.Human reproduction update · 2021Pooled it
- A State of the Science Review of Human Health Effects of the Michigan Polybrominated Biphenyl Contamination after Five Decades.Environmental health perspectives · 2025Review
- In-utero exposure to polybrominated biphenyl (PBB) and menstrual cycle function in adulthood.International journal of hygiene and environmental health · 2024Article
- Assessing Metabolic Differences Associated with Exposure to Polybrominated Biphenyl and Polychlorinated Biphenyls in the Michigan PBB Registry.Environmental health perspectives · 2023Article
- Elimination of PBB-153; findings from a cohort of Michigan adults.Environmental research · 2023Article
- The Launch of A Girl's First Period Study: Demystifying Reproductive Hormone Profiles in Adolescent Girls.Journal of pediatric and adolescent gynecology · 2022Article
- Menstrual cycle length and modern living: a review.Current opinion in endocrinology, diabetes, and obesity · 2021Review
- Brominated flame retardants and organochlorine pesticides and incidence of uterine leiomyomata: A prospective ultrasound study.Environmental epidemiology (Philadelphia, Pa.) · 2021Article
- Environmental toxicant exposure and menstrual cycle length.Current opinion in endocrinology, diabetes, and obesity · 2020Review
- Sex-specific DNA methylation differences in people exposed to polybrominated biphenyl.Epigenomics · 2020Article
- Hormonal Profiles of Menstrual Bleeding Patterns During the Luteal-Follicular Transition.The Journal of clinical endocrinology and metabolism · 2020Article
- Serum concentrations of polybrominated biphenyls (PBBs), polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs) in the Michigan PBB Registry 40 years after the PBB contamination incident.Environment international · 2020Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundBrominated flame retardants, including polybrominated biphenyls (PBB), are persistent compounds reported to affect sex hormones in animals; less is known about potential effects in humans. An industrial accident in 1973-1974 exposed Michigan residents to PBB through contaminated food. We examined whether this exposure to PBB had long-term effects on menstrual cycle function.
methodsIn 2004-2006, we recruited reproductive-aged women in the Michigan PBB Registry who were not pregnant, lactating, or taking hormonal medications. Participants kept daily diaries and provided daily urine samples for up to 6 months. We assayed the urine samples for estrone 3-glucuronide (E13G), pregnanediol 3-glucuronide (Pd3G), and follicle stimulating hormone (FSH). We fit linear mixed models among women aged 35-42 years to describe the relation between serum PBB levels and log-transformed, creatinine-adjusted daily endocrine levels among women who were premenarchal during the exposure incident in 1973-1974 (n = 70).
resultsWe observed that high (>3.0 parts per billion [ppb]) and medium (>1.0-3.0 ppb) PBB exposure were associated with lower E13G levels across the menstrual cycle and lower FSH levels during the follicular phase, compared with low PBB exposure (≤1.0 ppb). High PBB exposure was also associated with lower Pd3G levels across the cycle compared with low PBB exposure, whereas Pd3G levels were similar in women with medium and low PBB exposure.
conclusionOur results are consistent with a hypothesized effect of exposure to an exogenous estrogen agonist but the modest sample size of the study requires cautious interpretation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.