Evidence map›Paper›PMID 31180809›Full record

ReviewAnnual review of nutrition2019

Time-Restricted Eating to Prevent and Manage Chronic Metabolic Diseases.

Amandine Chaix, Emily N C Manoogian, Girish C Melkani, Satchidananda Panda

3 registry-linked trialsAbstract readReview
In one paragraph

Review in Annual review of nutrition, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 238 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
238citing papers in PubMed, 12 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05124847 nacompletednot on this mapstarted 2021, after this paper: background citation

Time Restricted Eating as a Treatment for Pediatric Obesity

TypeinterventionalSponsorFundación Pública Andaluza para la Investigación de Málaga en Biomedicina y SaludRan2021 to 2023Enrolled30ConditionsInfant Obesity, Hepatic Steatosis, Metabolic Syndrome, Insulin ResistanceArmsStandard Care, Time restricted eating
NCT06271200 narecruitingnot on this mapstarted 2024, after this paper: background citation

Effects of Intensive Lifestyle Interventions (ILI) on Weight Loss and Cardiometabolic Risks in Obese Adults With Metabolic Syndrome: A Randomized Clinical Trial

TypeinterventionalSponsorNational Health Research Institutes, TaiwanRan2024 to 2027Enrolled200ConditionsMetabolic SyndromeArmsStrategic lifestyle and drug interventions, Control
NCT07262593 naterminatednot on this mapstarted 2024, after this paper: background citation

Family-Based Meal Timing for Cancer Prevention Among Native Hawaiian and Other Pacific Islanders: FAMTIME

TypeinterventionalSponsorUniversity of UtahRan2024 to 2024Enrolled2ConditionsCancer PreventionArmsTime Restricted Eating (TRE), Medically Tailored Meals (MTM)
3 · Its place in the literature

Who cites it

238 citing papers in PubMed, 12 syntheses or guidelines pooled it.

  1. Understanding Participants' and Health Professionals' Perceptions and Experiences of Time-Restricted Eating: A Systematic Review of Qualitative Evidence.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026
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178 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Amandine ChaixRegulatory Biology Lab, Salk Institute for Biological Studies, La Jolla, California 92037, USA; email: satchin@salk.edu.
Emily N C ManoogianRegulatory Biology Lab, Salk Institute for Biological Studies, La Jolla, California 92037, USA; email: satchin@salk.edu.
Girish C MelkaniMolecular Biology Program and Heart Institute, Department of Biology, San Diego State University, San Diego, California 92182, USA.
Satchidananda PandaRegulatory Biology Lab, Salk Institute for Biological Studies, La Jolla, California 92037, USA; email: satchin@salk.edu.

Funding

Viral Vector Core (VVC)P30CA014195 · NCI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI Reuben Shaw · 1985 to 2026
$82.8M
Circadian Photoentrainment in MammalsR01EY016807 · NEI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI PANDA, SATCHIDANANDA · 2007 to 2019
$6.4M
Impact of Time-Restricted Feeding (TRF) on Glucose Homeostasis and Mitochondrial Function in Patients with Metabolic SyndromeR01DK118278 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Pam Rajendran Taub · 2018 to 2026
$5.3M
Diurnal rhythm in nutrient metabolism for metabolic homeostasisR01DK115214 · NIDDK · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI PANDA, SATCHIDANANDA · 2018 to 2020
$2.5M
NCI NIH HHS P30 CA014195NEI NIH HHS R01 EY016807NIDDK NIH HHS R01 DK115214NIDDK NIH HHS R01 DK118278
6 · The paper itself

Abstract

Molecular clocks are present in almost every cell to anticipate daily recurring and predictable changes, such as rhythmic nutrient availability, and to adapt cellular functions accordingly. At the same time, nutrient-sensing pathways can respond to acute nutrient imbalance and modulate and orient metabolism so cells can adapt optimally to a declining or increasing availability of nutrients. Organismal circadian rhythms are coordinated by behavioral rhythms such as activity-rest and feeding-fasting cycles to temporally orchestrate a sequence of physiological processes to optimize metabolism. Basic research in circadian rhythms has largely focused on the functioning of the self-sustaining molecular circadian oscillator, while research in nutrition science has yielded insights into physiological responses to caloric deprivation or to specific macronutrients. Integration of these two fields into actionable new concepts in the timing of food intake has led to the emerging practice of time-restricted eating. In this paradigm, daily caloric intake is restricted to a consistent window of 8-12 h. This paradigm has pervasive benefits on multiple organ systems.

Indexed as

MealsAnimalsBiological ClocksChronic DiseaseCircadian RhythmEatingFeeding BehaviorHumansMetabolic Diseasescircadian rhythmsmetabolic diseasetime-restricted eatingtime-restricted feeding

Identifiers

PMID31180809
PMCPMC6703924

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.