ArticleJournal of visualized experiments : JoVE2019
Convection Enhanced Delivery of Optogenetic Adeno-associated Viral Vector to the Cortex of Rhesus Macaque Under Guidance of Online MRI Images.
Article in Journal of visualized experiments : JoVE, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed.
- Multimodal Optical Imaging and Modulation with Simultaneous Electrophysiology Through Smart Dura in Non-Human Primates.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- A large-scale optogenetic neurophysiology platform for improving accessibility in non-human primate behavioral experiments.Nature communications · 2026Article
- Customizable artificial simulator for developing, planning, and training personnel on neurophysiology and surgical procedures in non-human primates.Journal of neuroscience methods · 2025Article
- A large-scale optogenetic neurophysiology platform for improving accessibility in non-human primate behavioral experiments.bioRxiv : the preprint server for biology · 2025Article
- Multimodal Optical Imaging and Modulation through Smart Dura in Non-Human Primates.bioRxiv : the preprint server for biology · 2025Article
- Inferring Neural Communication Dynamics from Field Potentials Using Graph Diffusion Autoregression.bioRxiv : the preprint server for biology · 2025Article
- An open-source MRI compatible frame for multimodal presurgical mapping in macaque and capuchin monkeys.Journal of neuroscience methods · 2024Article
- A Neural Implant Design Toolbox for Nonhuman Primates.Journal of visualized experiments : JoVE · 2024Article
- From imaging to precision: low cost and accurate determination of stereotactic coordinates for brain surgeryFrontiers in neuroscience · 2024Article
- Targeted Delivery of Chemogenetic Adeno-Associated Viral Vectors to Cortical Sulcus Regions in Macaque Monkeys by Handheld Injections.Bio-protocol · 2023Article
- Review
- Behavioral optogenetics in nonhuman primates; a psychological perspective.Current research in neurobiology · 2023Review
- Improving the Efficacy and Accessibility of Intracranial Viral Vector Delivery in Non-Human Primates.Pharmaceutics · 2022Article
- Demonstration of an Optimized Large-scale Optogenetic Cortical Interface for Non-human Primates.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2022Article
- Network structure mediates functional reorganization induced by optogenetic stimulation of non-human primate sensorimotor cortex.iScience · 2022Article
- A versatile toolbox for studying cortical physiology in primates.Cell reports methods · 2022Article
- Combining brain perturbation and neuroimaging in non-human primates.NeuroImage · 2021Review
- Multi-modal artificial dura for simultaneous large-scale optical access and large-scale electrophysiology in non-human primate cortex.Journal of neural engineering · 2021Article
- Red Light Optogenetics in Neuroscience.Frontiers in cellular neuroscience · 2021Review
- An Open Resource for Non-human Primate Optogenetics.Neuron · 2020Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
In non-human primate (NHP) optogenetics, infecting large cortical areas with viral vectors is often a difficult and time-consuming task. Here, we demonstrate the use of magnetic resonance (MR)-guided convection enhanced delivery (CED) of optogenetic viral vectors into primary somatosensory (S1) and motor (M1) cortices of macaques to obtain efficient, widespread cortical expression of light-sensitive ion channels. Adeno-associated viral (AAV) vectors encoding the red-shifted opsin C1V1 fused to yellow fluorescent protein (EYFP) were injected into the cortex of rhesus macaques under MR-guided CED. Three months post-infusion, epifluorescent imaging confirmed large regions of optogenetic expression (>130 mm
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.