ArticleGut microbes2020
Dietary iron variably modulates assembly of the intestinal microbiota in colitis-resistant and colitis-susceptible mice.
Article in Gut microbes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 55 citations in OpenAlex.
- The Gut-Iron-Immune Axis in Severe Anaemia and Bacteraemia.Nutrients · 2026Review
- Oridonin ameliorates ulcerative colitis by regulating the PI3K/AKT/mTOR signaling pathway to activate autophagy.International journal of molecular medicine · 2026Article
- Dietary iron and metal-based growth differentially modulate growth and gut microbiome of weaned piglets.Animal microbiome · 2026Article
- Organic Iron Supplementation in Cows and Its Impacts on Animal Health and Production.Animals : an open access journal from MDPI · 2025Article
- Dietary Iron Alleviates Dextran Sodium Sulfate-Induced Intestinal Injury by Regulating Regeneration of Intestinal Stem Cells in Weaned Mice.Biological trace element research · 2025Article
- Comparative analysis of dietary iron deprivation and supplementation in a murine model of colitis.FASEB bioAdvances · 2025Article
- Lysosomes finely control macrophage inflammatory function via regulating the release of lysosomal FeNature communications · 2025Article
- Citrus rhoifolin alleviated DSS-induced acute colitis by activating CEMIP/SLC7A11-mediated cystine uptake and inhibiting epithelial ferroptosis.European journal of nutrition · 2024Article
- The influence of iron nutrition on the development of intestine and immune cell divergency in neonatal pigs.Journal of animal science and biotechnology · 2024Article
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- Dietary iron intake has long-term effects on the fecal metabolome and microbiome.Metallomics : integrated biometal science · 2024Article
- Nutritional Characteristics, Health Impact, and Applications of Kefir.Foods (Basel, Switzerland) · 2024Review
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- Article
- Intravenous ferric carboxymaltose and ferric derisomaltose alter the intestinal microbiome in female iron-deficient anemic mice.Bioscience reports · 2023Article
- Role of iron in host-microbiota interaction and its effects on intestinal mucosal growth and immune plasticity in a piglet model.Science China. Life sciences · 2023Article
- Trace metal elements: a bridge between host and intestinal microorganisms.Science China. Life sciences · 2023Review
- Oral and intravenous iron treatment alter the gut microbiome differentially in dialysis patients.International urology and nephrology · 2023Article
- Kumatakenin inhibited iron-ferroptosis in epithelial cells from colitis mice by regulating the Eno3-IRP1-axis.Frontiers in pharmacology · 2023Article
- The role of iron in host-microbiota crosstalk and its effects on systemic glucose metabolism.Nature reviews. Endocrinology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
Abstract
Iron deficiency, a common comorbidity of gastrointestinal inflammatory disorders such as inflammatory bowel diseases (IBD), is often treated with oral iron supplementation. However, the safety of oral iron supplementation remains controversial because of its association with exacerbated disease activity in a subset of IBD patients. Because iron modulates bacterial growth and function, one possible mechanism by which iron may exacerbate inflammation in susceptible hosts is by modulating the intestinal microbiota. We, therefore, investigated the impact of dietary iron on the intestinal microbiota, utilizing the conventionalization of germ-free mice as a model of a microbial community in compositional flux to recapitulate the instability of the IBD-associated intestinal microbiota. Our findings demonstrate that altering intestinal iron availability during community assembly modulated the microbiota in non-inflamed wild type (WT) and colitis-susceptible interleukin-10-deficient (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.