Evidence map›Paper›PMID 31179783›Full record

ReviewExpert opinion on drug discovery2019

Cell death assays for neurodegenerative disease drug discovery.

Jeremy W Linsley, Terry Reisine, Steven Finkbeiner

Open access · greenAbstract readReview
In one paragraph

Review in Expert opinion on drug discovery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 32 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Jeremy W Linsleya Gladstone Center for Systems and Therapeutics , San Francisco , CA , USA.
Terry Reisineb Independent scientific consultant , Santa Cruz , CA , USA.
Steven Finkbeinera Gladstone Center for Systems and Therapeutics , San Francisco , CA , USA.
Gladstone Institutes · US

Funding

The proteasome in aging and neurodegenerative diseaseP01AG054407 · NIA · NORTHWESTERN UNIVERSITY · PI MORIMOTO, RICHARD I · 2018 to 2022
$14.0M
Neuron and Glial Cellular Signatures from Normal and Diseased iPS Cells-SupplementU54NS091046 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI FINKBEINER, STEVEN M, FRAENKEL, ERNEST · 2014 to 2020
$11.7M
Rare Variant Whole Genome Analysis and iPSC Validation of Putative Genetic Modifiers of Huntington DiseaseR37NS101996 · NINDS · J. DAVID GLADSTONE INSTITUTES · PI FINKBEINER, STEVEN M · 2017 to 2023
$4.4M
Dysfunction of the Autophagy-Lysosomal Pathway as a Common Mechanism of NeurodegenerationRF1AG058476 · NIA · J. DAVID GLADSTONE INSTITUTES · PI FINKBEINER, STEVEN M · 2017 to 2018
$4.1M
Tauopathy in AD and FTD - Molecular Determinants of Phenotypic DiversityRF1AG056151 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CARLSON, GEORGE A., DUFF, KAREN · 2017 to 2017
$4.1M
EXTRAMULAR RESEARCH FACILITIES CONSTRUCTIONC06RR018928 · NCRR · J. DAVID GLADSTONE INSTITUTES · PI MAHLEY, ROBERT W. · 2003 to 2003
$2.1M
Discovery of Novel Drugs that Increase Tau Clearance to Treat Alzheimer's DiseaseRF1AG058447 · NIA · J. DAVID GLADSTONE INSTITUTES · PI FINKBEINER, STEVEN M · 2018 to 2018
$1.8M
NCRR NIH HHS C06 RR018928NIA NIH HHS P01 AG054407NIA NIH HHS RF1 AG056151NIA NIH HHS RF1 AG058447NIA NIH HHS RF1 AG058476NINDS NIH HHS R37 NS101996NINDS NIH HHS U54 NS091046
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsCell DeathDrug DevelopmentDrug DiscoveryHigh-Throughput Screening AssaysHumansModels, BiologicalNeurodegenerative DiseasesPhenotype3D neurodegenerative disease modelscox proportional hazardhigh throughput screeninglongitudinal microscopyNeurodegenerative diseaseneurodegenerative disease modelsneuronal deathorganotypic slice culturerobotic microscopysingle cell analysis

Identifiers

PMID31179783
PMCPMC6663635
OpenAlexW2950163825

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.