Evidence map›Paper›PMID 31179610›Full record

ArticleOrthopaedic surgery2019

Prognostic Differences in Patients with Solitary and Multiple Spinal Metastases.

Deng-Xing Lun, Li-Na Xu, Feng Wang, Xiong-Gang Yang, Xiu-Chun Yu, Guo-Chuan Zhang, Yong-Cheng Hu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Orthopaedic surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Deng-Xing LunDepartment of Spine Surgery, Weifang People's Hospital, Weifang, China.ORCID https://orcid.org/0000-0002-0641-4517
Li-Na XuDepartment of Respiratory Medicine, Weifang People's Hospital, Weifang, China.ORCID https://orcid.org/0000-0002-0784-0294
Feng WangGraduate School, Tianjin Medical University, Tianjin, China.ORCID https://orcid.org/0000-0003-4073-7181
Xiong-Gang YangGraduate School, Tianjin Medical University, Tianjin, China.ORCID https://orcid.org/0000-0003-2354-3932
Xiu-Chun YuDepartment of Orthopaedic Oncology, Jinan Military General Hospital, Jinan, China.ORCID https://orcid.org/0000-0003-3443-8708
Guo-Chuan ZhangDepartment of Orthopaedic Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang, China.ORCID https://orcid.org/0000-0002-4256-6606
Yong-Cheng HuDepartment of Bone Oncology, Tianjin Hospital, Tianjin, China.ORCID https://orcid.org/0000-0001-7606-8640
Tianjin Medical University · CNWeifang People's Hospital · CNHebei Medical University · CNJinan Military General Hospital · CNTianjin Hospital · CN

Funding

National Natural Science Foundation of ChinaScience and Technology Fund of Tianjin Municipal Bureau of HealthTechnology of Tianjin Municipal Bureau of Health
6 · The paper itself

Abstract

objectivesTo investigate the association between the number of metastases to the spine and survival in patients with metastatic spinal cord compression (MSCC), as well as the prognosis difference between patients with solitary spinal metastasis (SSM) and multiple spinal metastases (MSM).

methodsThree institutional databases were searched to identify all patients who had undergone spinal surgery for metastatic spinal tumors between March 2002 and June 2010. As well as age and gender, preoperative medical conditions were collected from medical records, including primary tumor, preoperative Frankel score, other bone metastases, preoperative Karnofsky performance status (KPS), number of involved vertebrae, pathological fracture metastasis site, serum albumin, sphincter dysfunction and the time of developing motor deficits before surgery. Survival data were obtained from medical records or via telephone follow-ups. Univariate and multivariate predictors of overall survival for each group were assessed using the Cox proportional hazards model.

resultsThe median postoperative survival time was 6.0 ± 0.6 months (95% confidence interval [CI] 4.8-7.2) in patients with SSM and 7.0 ± 1.0 months (95% CI 5.1-8.9) in patients with MSM (P = 0.238). The difference in survival was not significant between groups. Furthermore, univariate analysis showed that the number of spinal metastases had no significant association with survival (P = 0.075). Primary tumor (P = 0.004) and preoperative KPS (P < 0.001) were independent prognostic factors in the whole cohort; primary tumor (P = 0.020), time of developing motor deficit (P = 0.041) and preoperative KPS (P = 0.038) were independent prognostic factors in patients with SSM; while preoperative KPS (P = 0.001) and serum album level (P < 0.001) were independent prognostic factors in patients with MSM.

conclusionThe number of spinal metastases has not proven to be useful in predicting the prognosis for patients with MSCC. Consequently, more aggressive operations should be considered for patients with multiple spinal metastases.

Indexed as

AdultAgedAged, 80 and overFemaleFollow-Up StudiesHumansMaleMiddle AgedPrognosisRetrospective StudiesSpinal Cord CompressionSpinal NeoplasmsSurvival AnalysisKarnofsky performance statusMetastatic spinal cord compressionMultiple spinal metastasisPrognostic factorsSpinal metastasis

Identifiers

PMID31179610
PMCPMC6595110
OpenAlexW2952561692

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.