Evidence map›Paper›PMID 31179602›Full record

ArticleGlia2019

Microglial proliferation and monocyte infiltration contribute to microgliosis following status epilepticus.

Lijie Feng, Madhuvika Murugan, Dale B Bosco, Yong Liu, Jiyun Peng, Gregory A Worrell, Hai-Long Wang, Lauren E Ta, Jason R Richardson, Yuxian Shen and 1 more

Open access · greenAbstract read
In one paragraph

Article in Glia, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 100 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Neuroinflammation and Disease: Pathways and Opportunities.Annual review of pharmacology and toxicology · 2026
    Review
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5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Lijie FengSchool of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui, China.
Madhuvika MuruganDepartment of Cell Biology and Neuroscience, School of Arts and Sciences, Rutgers University, Piscataway, New Jersey.
Dale B BoscoDepartment of Neurology, Mayo Clinic, Rochester, Minnesota.
Yong LiuDepartment of Neurology, Mayo Clinic, Rochester, Minnesota.
Jiyun PengDepartment of Cell Biology and Neuroscience, School of Arts and Sciences, Rutgers University, Piscataway, New Jersey.
Gregory A WorrellDepartment of Neurology, Mayo Clinic, Rochester, Minnesota.
Hai-Long WangDepartment of Neurology, Mayo Clinic, Rochester, Minnesota.
Lauren E TaDepartment of Neurology, Mayo Clinic, Rochester, Minnesota.
Jason R RichardsonDepartment of Environmental Health Sciences, Robert Stempel School of Public Health and Social Work, Florida International University, Miami, Florida.
Yuxian ShenSchool of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui, China.
Long-Jun WuDepartment of Cell Biology and Neuroscience, School of Arts and Sciences, Rutgers University, Piscataway, New Jersey.ORCID 0000-0001-8019-3380
Mayo Clinic · USRutgers, The State University of New Jersey · USAnhui Medical University · CNFlorida International University · US

Funding

The Role of Microglia in EpilepsyR01NS088627 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI WU, LONG-JUN · 2014 to 2023
$3.6M
Studying microglial function using cell ablation approachesR21DE025689 · NIDCR · RUTGERS, THE STATE UNIV OF N.J. · PI WU, LONG-JUN · 2016 to 2017
$431k
NIDCR NIH HHS R21 DE025689NINDS NIH HHS R01 NS088627
6 · The paper itself

Abstract

Microglial activation has been recognized as a major contributor to inflammation of the epileptic brain. Seizures are commonly accompanied by remarkable microgliosis and loss of neurons. In this study, we utilize the CX3CR1

Indexed as

Cell ProliferationAnimalsCalcium-Binding ProteinsCell DeathCX3C Chemokine Receptor 1Disease Models, AnimalGliosisHippocampusKainic AcidMaleMice, Inbred C57BLMice, TransgenicMicrofilament ProteinsMicrogliaMonocytesNeuronsAif1 protein, mouseCalcium-Binding ProteinsCcr2 protein, mouseCX3C Chemokine Receptor 1Cx3cr1 protein, mouseKainic AcidMicrofilament ProteinsReceptor, Macrophage Colony-Stimulating FactorReceptors, CCR2colony stimulating factor 1 receptorepilepsyinfiltrationmicrogliamonocytesproliferation

Identifiers

PMID31179602
PMCPMC6559368
OpenAlexW2933899143

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.