SynthesisJournal of magnetic resonance imaging : JMRI2020
Tractography reproducibility challenge with empirical data (TraCED): The 2017 ISMRM diffusion study group challenge.
Synthesis in Journal of magnetic resonance imaging : JMRI, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Meta-analysis of the normal diffusion tensor imaging values of the peripheral nerves in the upper limb.Scientific reports · 2023Pooled it
- Meta-analysis of the normal diffusion tensor imaging values of the median nerve and how they change in carpal tunnel syndrome.Scientific reports · 2021Pooled it
- Microscopy-informed structural connectivity mapping in the in vivo human brain via domain adaptation.bioRxiv : the preprint server for biology · 2026Article
- Longitudinal quantitative streamline tractography: robust estimation of white matter connectivity differences.bioRxiv : the preprint server for biology · 2026Article
- Analytic Bounds on GAMLSS Model Variability of Normative White Matter Brain Charts.bioRxiv : the preprint server for biology · 2026Article
- Analytic Bounds on GAMLSS Model Variability of Normative White Matter Brain Charts.Proceedings of SPIE--the International Society for Optical Engineering · 2026Article
- Imaging the structural connectome with hybrid MRI-microscopy tractography.Medical image analysis · 2025Article
- Deep Learning-Based Tract Classification of Preoperative DWI Tractography Advances the Prediction of Short-Term Postoperative Language Improvement in Children With Drug-Resistant Epilepsy.IEEE transactions on bio-medical engineering · 2025Article
- Real-Time Tractography-Assisted Neuronavigation for Transcranial Magnetic Stimulation.Human brain mapping · 2025Article
- Advances in Imaging of Compressive Neuropathies.Hand clinics · 2024Review
- Reproducibility of arterial spin labeling cerebral blood flow image processing: A report of the ISMRM open science initiative for perfusion imaging (OSIPI) and the ASL MRI challenge.Magnetic resonance in medicine · 2024Article
- Comparison of distortion correction preprocessing pipelines for DTI in the upper limb.Magnetic resonance in medicine · 2024Article
- Structural Fingerprinting of the Frontal Aslant Tract: Predicting Cognitive Control Capacity and Obsessive-Compulsive Symptoms.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Tractography passes the test: Results from the diffusion-simulated connectivity (disco) challenge.NeuroImage · 2023Article
- Future Considerations in the Diagnosis and Treatment of Compressive Neuropathies of the Upper Extremity.Journal of hand surgery global online · 2023Review
- Structural and functional connectivity of the inferior temporal numeral area.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- The influence of regions of interest on tractography virtual dissection protocols: general principles to learn and to follow.Brain structure & function · 2022Article
- The Case for Optimized Edge-Centric Tractography at Scale.Frontiers in neuroinformatics · 2022Article
- MASiVar: Multisite, multiscanner, and multisubject acquisitions for studying variability in diffusion weighted MRI.Magnetic resonance in medicine · 2021Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
43 authors.
Funding
Abstract
backgroundFiber tracking with diffusion-weighted MRI has become an essential tool for estimating in vivo brain white matter architecture. Fiber tracking results are sensitive to the choice of processing method and tracking criteria. PURPOSE: To assess the variability for an algorithm in group studies reproducibility is of critical context. However, reproducibility does not assess the validity of the brain connections. Phantom studies provide concrete quantitative comparisons of methods relative to absolute ground truths, yet do no capture variabilities because of in vivo physiological factors. The ISMRM 2017 TraCED challenge was created to fulfill the gap. STUDY TYPE: A systematic review of algorithms and tract reproducibility studies. SUBJECTS: Single healthy volunteers. FIELD STRENGTH/SEQUENCE: 3.0T, two different scanners by the same manufacturer. The multishell acquisition included b-values of 1000, 2000, and 3000 s/mm ASSESSMENT: Nine international groups submitted 46 tractography algorithm entries each consisting 16 tracts per scan. The algorithms were assessed using intraclass correlation (ICC) and the Dice similarity measure. STATISTICAL TESTS: Containment analysis was performed to assess if the submitted algorithms had containment within tracts of larger volume submissions. This also serves the purpose to detect if spurious submissions had been made.
resultsThe top five submissions had high ICC and Dice >0.88. Reproducibility was high within the top five submissions when assessed across sessions or across scanners: 0.87-0.97. Containment analysis shows that the top five submissions are contained within larger volume submissions. From the total of 16 tracts as an outcome relatively the number of tracts with high, moderate, and low reproducibility were 8, 4, and 4. DATA
conclusionThe different methods clearly result in fundamentally different tract structures at the more conservative specificity choices. Data and challenge infrastructure remain available for continued analysis and provide a platform for comparison. LEVEL OF EVIDENCE: 5 Technical Efficacy Stage: 1 J. Magn. Reson. Imaging 2020;51:234-249.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.