Evidence map›Paper›PMID 31179547›Full record

ReviewEpilepsia2019

WONOEP appraisal: Network concept from an imaging perspective.

Robert C Wykes, Hui Ming Khoo, Lorenzo Caciagli, Hal Blumenfeld, Peyman Golshani, Jaideep Kapur, John M Stern, Andrea Bernasconi, Stefanie Dedeurwaerdere, Neda Bernasconi

Open access · greenAbstract readReview
In one paragraph

Review in Epilepsia, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Cycles in epilepsy.Nature reviews. Neurology · 2021
    Review
  9. Article
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 5 countries.

Robert C WykesDepartment of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, UK.ORCID 0000-0002-6141-6822
Hui Ming KhooMontreal Neurological Institute and Hospital, McGill University, Montreal, Canada.ORCID 0000-0002-4039-0520
Lorenzo CaciagliDepartment of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, UK.ORCID 0000-0001-7189-9699
Hal BlumenfeldDepartment of Neurology, Neuroscience and Neurosurgery, Yale University School of Medicine, New Haven, Connecticut.
Peyman GolshaniDepartment of Neurology, Geffen School of Medicine, UCLA, Los Angeles, California.
Jaideep KapurSchool of Medicine, University of Virginia, Charlottesville, Virginia.
John M SternDepartment of Neurology, Geffen School of Medicine, UCLA, Los Angeles, California.
Andrea BernasconiNeuroimaging of Epilepsy Laboratory, Department of Neurosciences and McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.ORCID 0000-0001-9358-5703
Stefanie DedeurwaerdereNeuroscience TA, UCB BioPharma, Braine-l-Alleud, Belgium.
Neda BernasconiNeuroimaging of Epilepsy Laboratory, Department of Neurosciences and McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
Montreal Neurological Institute and Hospital · CAUniversity of California, Los Angeles · USNational Hospital for Neurology and Neurosurgery · GBUCB Pharma (Belgium) · BEUniversity of Virginia · USYale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
UCLA Center for Translational Research in Neurodevelopment: UC-TRaNU54HD087101 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MCCRACKEN, JAMES T. · 2016 to 2020
$6.5M
TREATMENT OF STATUS EPILEPTICUSR01NS040337 · NINDS · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI KAPUR, JAIDEEP · 2000 to 2021
$5.0M
Neurosteroid Regulation of SeizuresR01NS044370 · NINDS · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI KAPUR, JAIDEEP · 2003 to 2017
$4.1M
Building and sharing next generation open-source, wireless, multichannel miniaturized microsopes for imaging activity in freely behaving miceU01NS094286 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GOLSHANI, PEYMAN, KHAKH, BALJIT · 2015 to 2017
$2.7M
Epilepsy related cell loss and cognitive dysfunctionR01NS099137 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GOLSHANI, PEYMAN, HOUSER, CAROLYN R · 2017 to 2021
$2.1M
Brain Research UKCanadian Institute of Health Research 123520Canadian Institute of Health Research MOP-57840Epilepsy Research UK FellowshipJapan Epilepsy Research FoundationMark Rayport and Shirley Ferguson Rayport Clinical Fellowship in Epilepsy SurgeryNCATS NIH HHS UL1 TR001863NICHD NIH HHS U54 HD087101NIH HHS R01 NS040337NIH HHS R01 NS099137NINDS NIH HHS R01 NS040337NINDS NIH HHS R01 NS044370NINDS NIH HHS R01 NS099137NINDS NIH HHS U01 NS094286Osaka Medical Research Foundation for Intractable Diseases (Japan)Preston Robb Fellowship of the Montreal Neurological Institute (Canada)Research fellowship of the Uehara Memorial Foundation (Japan)
6 · The paper itself

Abstract

Neuroimaging techniques applied to a variety of organisms-from zebrafish, to rodents to humans-can offer valuable insights into neuronal network properties and their dysfunction in epilepsy. A wide range of imaging methods used to monitor neuronal circuits and networks during evoked seizures in animal models and advances in functional magnetic resonance imaging (fMRI) applied to patients with epilepsy were discussed during the XIV Workshop on Neurobiology of Epilepsy (XIV WONOEP) organized in 2017 by the Neurobiology Commission of the International League Against Epilepsy (ILAE). We review the growing number of technological approaches developed, as well as the current state of knowledge gained from studies applying these advanced imaging approaches to epilepsy research.

Indexed as

Functional NeuroimagingAnimalsBrainDrug Resistant EpilepsyEducationEpilepsyEpilepsy, Temporal LobeHumanscalcium imagingepileptic networksfMRIgraph theoryneuroimaging

Identifiers

PMID31179547
PMCPMC6667743
OpenAlexW2952927026

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.