Evidence map›Paper›PMID 31179538›Full record

ArticleCancer2019

Body fat distribution on computed tomography imaging and prostate cancer risk and mortality in the AGES-Reykjavik study.

Barbra A Dickerman, Johanna E Torfadottir, Unnur A Valdimarsdottir, Edward Giovannucci, Kathryn M Wilson, Thor Aspelund, Laufey Tryggvadottir, Lara G Sigurdardottir, Tamara B Harris, Lenore J Launer and 3 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 5 pooled it
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 5 syntheses or guidelines pooled it, 56 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 3 countries.

Barbra A DickermanDepartment of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.ORCID 0000-0003-2843-687X
Johanna E TorfadottirCentre for Public Health Sciences, University of Iceland, Reykjavik, Iceland.
Unnur A ValdimarsdottirDepartment of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.
Edward GiovannucciDepartment of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.
Kathryn M WilsonDepartment of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.
Thor AspelundCentre for Public Health Sciences, University of Iceland, Reykjavik, Iceland.
Laufey TryggvadottirIcelandic Cancer Registry, Reykjavik, Iceland.
Lara G SigurdardottirCentre for Public Health Sciences, University of Iceland, Reykjavik, Iceland.
Tamara B HarrisLaboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute on Aging, Bethesda, Maryland.
Lenore J LaunerLaboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute on Aging, Bethesda, Maryland.
Vilmundur GudnasonIcelandic Cancer Registry, Reykjavik, Iceland.
Sarah C MarktDepartment of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.
Lorelei A MucciDepartment of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.
University of Iceland · ISBrigham and Women's Hospital · USHarvard University · USNational Institute on Aging · USIcelandic Heart Association · IS

Funding

Tumor and Circulating Markers as Links Between Obesity and Lethal Prostate CanceP50CA090381 · NCI · DANA-FARBER CANCER INSTITUTE · PI LODA, MASSIMO · 2002 to 2017
$36.2M
Training Program in Cancer EpidemiologyT32CA009001 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI A. Heather Eliassen, Meir Stampfer · 1985 to 2026
$17.3M
CLINICAL PROJECT: Age, Gene/Environment Susceptibility Study on the Multi-omics of Aging: A clinical epidemiologic prospective studyZIAAG007380 · NIA · NATIONAL INSTITUTE ON AGING · PI LAUNER, LENORE J · 2009 to 2025
$6.1M
AGES STUDY-THE REYKJAVIK STUDY OF HEALTHY AGING FOR THE NEW MILLENNIUM-26012100N01AG012100 · NIA · ICELANDIC HEART ASSOCIATION · 2002 to 2004
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NCI NIH HHS P50 CA090381NCI NIH HHS T32 CA009001NIA NIH HHS N01 AG012100
6 · The paper itself

Abstract

backgroundThe World Cancer Research Fund classifies as "strong evidence" the link between obesity and the risk of advanced prostate cancer. In light of the different hormonal profiles associated with where adipose is stored, this study investigated the role of objectively measured body fat distribution and the risk of clinically relevant prostate cancer.

methodsThis was a prospective study of 1832 men in the Age, Gene/Environment Susceptibility-Reykjavik study. From 2002 to 2006, participants underwent baseline computed tomography imaging of fat deposition, bioelectric impedance analysis, and measurement of body mass index (BMI) and waist circumference. Men were followed through linkage with nationwide cancer registries for the incidence of total (n = 172), high-grade (Gleason grade ≥8; n = 43), advanced (≥cT3b/N1/M1 at diagnosis or fatal prostate cancer over follow-up; n = 41), and fatal prostate cancer (n = 31) through 2015. Cox regression was used to evaluate the association between adiposity measures and prostate cancer outcomes.

resultsAmong all men, visceral fat (hazard ratio [HR], 1.31 per 1-standard deviation [SD] increase; 95% confidence interval [CI], 1.00-1.72) and thigh subcutaneous fat (HR, 1.37 per 1-SD increase; 95% CI, 1.00-1.88) were associated with risk of advanced and fatal disease, respectively. Among men who were leaner based on BMI, visceral fat was associated with both advanced and fatal disease. BMI and waist circumference were associated with a higher risk of advanced and fatal disease. No adiposity measures were associated with total or high-grade disease.

conclusionsSpecific fat depots as well as BMI and waist circumference were associated with the risk of aggressive prostate cancer, which may help to elucidate underlying mechanisms and target intervention strategies.

Indexed as

Body Fat DistributionAdiposityAgedBody Mass IndexHumansIcelandIncidenceIntra-Abdominal FatMaleProportional Hazards ModelsProspective StudiesProstatic NeoplasmsRisk FactorsTomography, X-Ray ComputedWaist Circumferenceadipositycohortcomputed tomographyfat distributionobesityprostate cancervisceral fat

Identifiers

PMID31179538
PMCPMC6663585
OpenAlexW2948155339

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.