ArticleCurrent opinion in physiology2019
The rhythm section: An update on spinal interneurons setting the beat for mammalian locomotion.
Article in Current opinion in physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Spatial and network principles behind neural generation of locomotion.Nature communications · 2026Article
- Review
- Article
- Properties of rhythmogenic currents in spinal Shox2 interneurons across postnatal development.The Journal of physiology · 2025Article
- Article
- The spinal premotor network driving scratching flexor and extensor alternation.bioRxiv : the preprint server for biology · 2025Article
- Excitatory Spinal Lhx9-Derived Interneurons Modulate Locomotor Frequency in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Distinguishing subtypes of spinal locomotor neurons to inform circuit function and dysfunction.Current opinion in neurobiology · 2023Review
- Rare phenomena of central rhythm and pattern generation in a case of complete spinal cord injury.Nature communications · 2023Article
- Spinal Basis of Direction Control during Locomotion in Larval Zebrafish.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Upregulation of breathing rate during running exercise by central locomotor circuits in mice.Nature communications · 2023Article
- Deconstructing the modular organization and real-time dynamics of mammalian spinal locomotor networks.Nature communications · 2023Article
- Article
- The role of V3 neurons in speed-dependent interlimb coordination during locomotion in mice.eLife · 2022Article
- Identification of adult spinal Shox2 neuronal subpopulations based on unbiased computational clustering of electrophysiological properties.Frontiers in neural circuits · 2022Article
- Modular organization of locomotor networks in people with severe spinal cord injury.Frontiers in neuroscience · 2022Article
- Asymmetric and transient properties of reciprocal activity of antagonists during the paw-shake response in the cat.PLoS computational biology · 2021Article
- A medullary centre for lapping in mice.Nature communications · 2021Article
- Elimination of glutamatergic transmission from Hb9 interneurons does not impact treadmill locomotion.Scientific reports · 2021Article
- Spinal Cord Injury Alters Spinal Shox2 Interneurons by Enhancing Excitatory Synaptic Input and Serotonergic Modulation While Maintaining Intrinsic Properties in Mouse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
To initiate and support locomotion, rhythm generating neurons in the spinal central pattern generator convert descending input into a rhythmic signal which is conveyed to downstream neurons, leading to the recruitment of motor neurons and activation of muscles. Although two genetically-defined neuronal populations have been linked to rhythm generation, a single all-inclusive rhythm generating population has yet to be identified. Here, we consolidate recent work aimed at identifying rhythm generating neurons, summarize the evidence for the involvement of two neuronal populations in rhythm generation, describe the challenges in identifying a marker for rhythm generating neurons, and discuss potential directions to take in integrating spinal rhythm generating neurons into recently identified speed-dependent locomotor circuits.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.