ArticleCurrent opinion in behavioral sciences2015
The good, the bad and the brain: Neural correlates of appetitive and aversive values underlying decision making.
Article in Current opinion in behavioral sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05866575 (Prediction of the Therapeutic Response in Depression Based on an Early Neuro-computational Modeling Assessment of Motivation), which is not on this map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prediction of the Therapeutic Response in Depression Based on an Early Neuro-computational Modeling Assessment of Motivation
Who cites it
38 citing papers in PubMed.
- Impaired Learning From Negative Feedback in Stimulant Use Disorder: Dopaminergic Modulation.The international journal of neuropsychopharmacology · 2021Trial
- In Cocaine Dependence, Neural Prediction Errors During Loss Avoidance Are Increased With Cocaine Deprivation and Predict Drug Use.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2019Trial
- Complementary and opponent value signals in the human brain support choosing the best and avoiding the worst.Nature communications · 2026Article
- When effort fuels risk: Cognitive exertion increases risk-taking for gains but reduces it for losses.Cognitive, affective & behavioral neuroscience · 2026Article
- Diffusion connectometry reveals white matter substrates of individual differences in loss aversion.Scientific reports · 2025Article
- Neurocomputational mechanisms underlying the distinct motivational influences of reward and punishment on cognitive control.bioRxiv : the preprint server for biology · 2025Article
- Deconstructing neural predictors of risky choice.PNAS nexus · 2025Article
- Morphometric Evidence of a U-Shaped Relationship Between Loss Aversion and Posterior Insular/Somatosensory Cortical Features.Human brain mapping · 2025Article
- Examining neuroanatomical correlates of win-stay, lose-shift behaviour.Brain structure & function · 2025Article
- Neural and Computational Mechanisms of Motivation and Decision-making.Journal of cognitive neuroscience · 2024Article
- Neural interactions in the human frontal cortex dissociate reward and punishment learning.eLife · 2024Article
- From compulsivity to compulsion: the neural basis of compulsive disorders.Nature reviews. Neuroscience · 2024Review
- Appetitive and aversive cue reactivities differentiate neural subtypes of alcohol drinkers.Addiction neuroscience · 2023Article
- Article
- Threat and Reward Imminence Processing in the Human Brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- RISK aversion in Italian forensic and non-forensic patients with schizophrenia spectrum disorders.PloS one · 2023Article
- Laser stimulation of the skin for quantitative study of decision-making and motivation.Cell reports methods · 2022Article
- Intracerebral mechanisms explaining the impact of incidental feedback on mood state and risky choice.eLife · 2022Article
- Aversive motivation and cognitive control.Neuroscience and biobehavioral reviews · 2022Review
- Dissociable influences of reward and punishment on adaptive cognitive control.PLoS computational biology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Approaching rewards and avoiding punishments could be considered as core principles governing behavior. Experiments from behavioral economics have shown that choices involving gains and losses follow different policy rules, suggesting that appetitive and aversive processes might rely on different brain systems. Here we contrast this hypothesis with recent neuroscience studies exploring the human brain from brainstem nuclei to cortical areas. Although some circuits show rigid specialization, many others appear to process both appetitive and aversive stimuli, in a flexible manner that depends on a context-wise subjective reference point. Moreover, appetitive and aversive aspects are often integrated into net values that are signaled with enhanced activity in 'positive regions', and suppressed activity in 'negative regions'. This dichotomy might explain why drugs or lesions can produce valence-specific effects, biasing decisions towards approaching a reward or avoiding a punishment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.