Evidence map›Paper›PMID 31179333›Full record

ArticleBioMed research international2019

Shenqi Fuzheng Injection (SFI) Enhances IFN-

Xiaoheng Chen, Shuo Qi, Zhe Li, Bei He, Hui Long Li, Jinxiang Fu, Sheng Huang, Lei Zhang, Xinai Li, Rui Hu and 9 more

Abstract readValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Xiaoheng ChenDepartment of Surgery, Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing, China.ORCID 0000-0002-7558-5299
Shuo QiDepartment of Surgery, Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing, China.ORCID 0000-0001-7559-4606
Zhe LiDepartment of Surgery, Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing, China.
Bei HeDepartment of Medical Service, The Third Clinical Medical College of Beijing University of Chinese Medicine, Beijing, China.
Hui Long LiDepartment of Surgery, Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing, China.
Jinxiang FuDepartment of Surgery, Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing, China.
Sheng HuangDepartment of Surgery, Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing, China.
Lei ZhangDepartment of Surgery, Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing, China.
Xinai LiDepartment of Surgery, Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing, China.
Rui HuDepartment of Surgery, Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing, China.
Lu LiDepartment of Surgery, Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing, China.
Tangshun WangDepartment of Surgery, Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing, China.
Feng XueDepartment of Surgery, Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing, China.
Xiang GaoDepartment of Surgery, Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing, China.
Xiaoguang ShiDepartment of Surgery, Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing, China.
Tao ZhangDepartment of Surgery, Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing, China.
Xin WangDepartment of Surgery, Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing, China.
Junhui WangDepartment of Physiology, Faculty of Medicine, University of Toronto, Toronto, Canada.
Zhiguo DingDepartment of Surgery, Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing, China.ORCID 0000-0003-3955-9779

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Shenqi Fuzheng Injection (SFI) is a traditional Chinese medicine injection with anticancer properties and is mainly composed of ginseng and astragalus. Its efficacy has been confirmed in clinical trials, but the mechanism remains unclear. We investigated the effect of SFI on vascular endothelial growth factor (VEGF) gene expression in hepatocellular carcinoma (HCC) cells and identified its possible mechanism of synergistic effects when combined with the chemotherapeutic drug interferon (IFN-)

Indexed as

Gene SilencingCarcinoma, HepatocellularDrugs, Chinese HerbalGene Expression Regulation, NeoplasticHumansInterferon-alphaLiver NeoplasmsNeoplasm ProteinsVascular Endothelial Growth Factor ADrugs, Chinese HerbalInterferon-alphaNeoplasm Proteinsshenqi fuzhengVascular Endothelial Growth Factor AVEGFA protein, human

Identifiers

PMID31179333
PMCPMC6507437

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.