Evidence map›Paper›PMID 31179323›Full record

ReviewBioMed research international2019

Eradication of HCV Infection with the Direct-Acting Antiviral Therapy in Renal Allograft Recipients.

Armando Calogero, Evangelista Sagnelli, Massimiliano Creta, Silvia Angeletti, Gaia Peluso, Paola Incollingo, Maria Candida, Gianluca Minieri, Nicola Carlomagno, Concetta Anna Dodaro and 2 more

Erratum issuedAbstract readReview
In one paragraph

Review in BioMed research international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Observational
  4. Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Armando CalogeroDepartment of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy.ORCID 0000-0003-2315-0610
Evangelista SagnelliDepartment of Mental Health and Public Medicine, University of Campania Luigi Vanvitelli, Naples, Italy.ORCID 0000-0003-2817-8436
Massimiliano CretaDepartment of Neurosciences, Human Reproduction and Odontostomatology, University of Naples Federico II, Naples, Italy.
Silvia AngelettiUnit of Clinical Laboratory Science, University Campus Bio-Medico of Rome, Rome, Italy.ORCID 0000-0002-7393-8732
Gaia PelusoDepartment of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy.ORCID 0000-0003-4512-4579
Paola IncollingoDepartment of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy.ORCID 0000-0001-5116-1451
Maria CandidaDepartment of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy.
Gianluca MinieriDepartment of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy.
Nicola CarlomagnoDepartment of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy.
Concetta Anna DodaroDepartment of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy.
Massimo CiccozziUnit of Medical Statistic and Molecular Epidemiology, University Campus Bio-Medico, Rome, Italy.
Caterina SagnelliDepartment of Mental Health and Public Medicine, University of Campania Luigi Vanvitelli, Naples, Italy.ORCID 0000-0002-6413-7810

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatitis C virus (HCV) infection unfavorably affects the survival of both renal patients undergoing hemodialysis and renal transplant recipients. In this subset of patients, the effectiveness and safety of different combinations of interferon-free direct-acting antiviral agents (DAAs) have been analyzed in several small studies. Despite fragmentary, the available data demonstrate that DAA treatment is safe and effective in eradicating HCV infection, with a sustained virologic response (SVR) rates nearly 95% and without an increased risk of allograft rejection. This review article analyzes the results of most published studies on this topic to favor more in-depth knowledge of the readers on the subject. We suggest, however, perseverating in this update as the optimal DAA regimen may not be proposed yet, because of the expected arrival of newer DAAs and of the lack of data from large multicenter randomized controlled trials.

Indexed as

HepacivirusKidney TransplantationSustained Virologic ResponseTransplant RecipientsAntiviral AgentsHepatitis C, ChronicHumansTransplantation, HomologousAntiviral Agents

Identifiers

PMID31179323
PMCPMC6507153

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.