ArticleAnnals of translational medicine2019
Pregnancy and Wilson disease: management and outcome of mother and newborns-experiences of a perinatal centre.
Article in Annals of translational medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- APASL clinical practice guidance: the diagnosis and management of patients with Wilson's disease.Hepatology international · 2026Article
- Unable to walk or eat without assistance in pregnancy-Wilson's disease in a resource-limited and conflict-affected setting: a case report.Journal of medical case reports · 2026Article
- Successful Pregnancies Following Liver Transplantation for Wilson's Disease: A Case Report and Literature Review.Clinical case reports · 2026Article
- Case Report: Long-standing multisystem Wilson's disease in a pregnant woman with prolonged chelation discontinuation.Frontiers in medicine · 2026Article
- Maternal and Fetal Outcomes of Pregnancies in Wilson's Disease: A Single-Centre Real-Life Experience.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2025Article
- Pregnancy With Wilson's Disease.Maternal-fetal medicine (Wolters Kluwer Health, Inc.) · 2024Article
- Outcomes of pregnancy in Wilson's disease: a population-based study from multiple centres of the Han population in China.Frontiers in medicine · 2024Article
- A Century of Progress on Wilson Disease and the Enduring Challenges of Genetics, Diagnosis, and Treatment.Biomedicines · 2023Article
- [Pregnancy management in patients with hepatolenticular degeneration].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2022Review
- The Maternal and Fetal Outcomes of Pregnancy in Wilson's Disease: A Systematic Literature Review and Meta-Analysis.Biomedicines · 2022Review
- Article
- Wilson disease in Northern Portugal: a long-term follow-up study.Orphanet journal of rare diseases · 2022Article
- [Management of hepatolenticular degeneration during pregnancy].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2022Article
- The Role of Fe, Zn, and Cu in Pregnancy.Biomolecules · 2020Review
- Wilson disease and pregnancy.Clinical liver diseaseReview
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWilson disease is an autosomal recessive genetic disorder affecting copper transport leading to hepatic and/or neuropsychiatric manifestation. Untreated Wilson disease in females may cause sub fertility or spontaneous miscarriage. Although the literature shows an increasing number of successful outcomes after treatment, pregnant patients with Wilson disease still need close monitoring and interdisciplinary management.
methodsIn a retrospective study patient charts of 32 pregnancies in 22 women with Wilson disease were reviewed retrospectively for the initial clinical manifestation, medical treatment prior and during pregnancy, maternal and fetal course and outcome.
resultsA total of 32 pregnancies in 22 patients were analyzed. The majority of our patients did not have any deterioration of symptoms of Wilson disease prior to and during pregnancy. One pregnant patient decided to stop her anticopper medications while pregnant with fatal outcome for both, mother and foetus. None of our newborns showed major birth defects or side effects in this cohort after maternal chelation treatment.
conclusionsReproductive status and pregnancies of women with Wilson disease may be problematic. Pregnant women need close monitoring and multidisciplinary management. Anticopper therapy during pregnancy and breast feeding are safe. Treatment should be maintained during pregnancy and the pregnant women should be treated by a multi-disciplinary team. With adequate medical treatment and close monitoring before and during pregnancy, a successful outcome of mother and newborn can be achieved.
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Registered trials
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