Evidence map›Paper›PMID 31178967›Full record

Trial reportOxidative medicine and cellular longevity2019

Additional Effects of Nutritional Antioxidant Supplementation on Peripheral Muscle during Pulmonary Rehabilitation in COPD Patients: A Randomized Controlled Trial.

Fares Gouzi, Jonathan Maury, Nelly Héraud, Nicolas Molinari, Héléna Bertet, Bronia Ayoub, Marine Blaquière, François Bughin, Philippe De Rigal, Magali Poulain and 7 more

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Oxidative medicine and cellular longevity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01942889 (Antioxidants Supplementation Associated With Pulmonary Rehabilitation is it Effective on Muscle Dysfunction and Signaling Pathways Involved in the Myopathy of COPD?), which is not on this map. Cited by 28 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 8 pooled it
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01942889 nacompletednot on this map

Antioxidants Supplementation Associated With Pulmonary Rehabilitation is it Effective on Muscle Dysfunction and Signaling Pathways Involved in the Myopathy of COPD?

TypeinterventionalSponsorUniversity Hospital, MontpellierRan2012 to 2014Enrolled64ConditionsChronic Obstructive Pulmonary Disease, COPDArmsAntioxidant Supplementation associated to Comprehensive respiratory Rehabilitation Program
3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 8 syntheses or guidelines pooled it, 37 citations in OpenAlex.

  1. Effects of exercise on muscle fatigability in COPD: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2025
    Pooled it
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  5. Guideline
  6. Pooled it
  7. Pooled it
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  9. Review
  10. Article
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  12. Medical nutrition therapy in chronic obstructive pulmonary disease: A narrative review.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2025
    Review
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  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 2 countries.

Fares Gouzi *PhyMedExp, Montpellier University, INSERM U1046, CNRS UMR 9214, Montpellier University Hospital, France.ORCID 0000-0001-8970-866X
Jonathan Maury *PhyMedExp, Montpellier University, INSERM U1046, CNRS UMR 9214, France.
Nelly HéraudPulmonary Rehabilitation Centers Les Cliniques du Souffle®, 5 Santé/Fontalvie Corporation, 66350 Toulouges, France.
Nicolas MolinariIMAG, CNRS, Montpellier University, Montpellier University Hospital, Montpellier, France.
Héléna BertetIMAG, CNRS, Montpellier University, Montpellier University Hospital, Montpellier, France.
Bronia AyoubPhyMedExp, Montpellier University, INSERM U1046, CNRS UMR 9214, Montpellier University Hospital, France.
Marine BlaquièrePhyMedExp, Montpellier University, INSERM U1046, CNRS UMR 9214, Montpellier University Hospital, France.
François BughinPhyMedExp, Montpellier University, INSERM U1046, CNRS UMR 9214, Montpellier University Hospital, France.
Philippe De RigalPulmonary Rehabilitation Centers Les Cliniques du Souffle®, 5 Santé/Fontalvie Corporation, 66350 Toulouges, France.
Magali PoulainPulmonary Rehabilitation Centers Les Cliniques du Souffle®, 5 Santé/Fontalvie Corporation, 66350 Toulouges, France.
Joël PincemailDepartment of Cardiovascular Surgery and CREDEC, University of Liège, Sart Tilman University Hospital, 4000 Liège, Belgium.
Jean-Paul CristolPhyMedExp, Montpellier University, INSERM U1046, CNRS UMR 9214, Montpellier University Hospital, France.ORCID 0000-0001-8563-7278
Dalila Laoudj-ChenivessePhyMedExp, Montpellier University, INSERM U1046, CNRS UMR 9214, France.
Jacques MercierPhyMedExp, Montpellier University, INSERM U1046, CNRS UMR 9214, Montpellier University Hospital, France.
Christian PréfautMontpellier University, France.
Pascal PomièsPhyMedExp, Montpellier University, INSERM U1046, CNRS UMR 9214, France.ORCID 0000-0002-5301-6087
Maurice HayotPhyMedExp, Montpellier University, INSERM U1046, CNRS UMR 9214, Montpellier University Hospital, France.
Centre National de la Recherche Scientifique · FRUniversité de Montpellier · FRUniversity of Liège · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSkeletal muscle dysfunction in patients with chronic obstructive pulmonary disease (COPD) is not fully reversed by exercise training. Antioxidants are critical for muscle homeostasis and adaptation to training. However, COPD patients experience antioxidant deficits that worsen after training and might impact their muscle response to training. Nutritional antioxidant supplementation in combination with pulmonary rehabilitation (PR) would further improve muscle function, oxidative stress, and PR outcomes in COPD patients.

methodsSixty-four COPD patients admitted to inpatient PR were randomized to receive 28 days of oral antioxidant supplementation targeting the previously observed deficits (PR antioxidant group;

resultsEighty-one percent of the patients (FEV

conclusionsWhile the primary outcome was not significantly improved, COPD patients demonstrate significant improvements of secondary outcomes (muscle strength and other training-refractory outcomes), suggesting a potential "add-on" effect of the nutritional antioxidant supplementation (vitamins C and E, zinc, and selenium) during PR. This trial is registered with NCT01942889.

Indexed as

AdultAgedDietary SupplementsFemaleHumansLungMaleMiddle AgedMuscle, SkeletalPulmonary Disease, Chronic Obstructive

Identifiers

PMID31178967
PMCPMC6501222
OpenAlexW2937030029

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.