Evidence map›Paper›PMID 31178957›Full record

ArticleOxidative medicine and cellular longevity2019

Inhibition of Mitofusin-2 Promotes Cardiac Fibroblast Activation via the PERK/ATF4 Pathway and Reactive Oxygen Species.

Yanguo Xin, Wenchao Wu, Jing Qu, Xiaojiao Wang, Song Lei, Lixing Yuan, Xiaojing Liu

Erratum issuedOpen access · hybridAbstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
  2. Article
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  5. Review
  6. Review
  7. Overview of miR-106a Regulatory Roles: from Cancer to Aging.Bioengineering (Basel, Switzerland) · 2023
    Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Role of the central renin‑angiotensin system in hypertension (Review).International journal of molecular medicine · 2021
    Review
  16. Article
  17. Mitofusin-2: A New Mediator of Pathological Cell Proliferation.Frontiers in cell and developmental biology · 2021
    Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Yanguo XinDepartment of Cardiology, West China Hospital, Sichuan University, Chengdu 610041, China.ORCID 0000-0002-1405-0733
Wenchao WuLaboratory of Cardiovascular Diseases, Regenerative Medicine Research Center, West China Hospital, Sichuan University, Chengdu 610041, China.ORCID 0000-0002-9919-0822
Jing QuLaboratory of Cardiovascular Diseases, Regenerative Medicine Research Center, West China Hospital, Sichuan University, Chengdu 610041, China.ORCID 0000-0001-9824-8570
Xiaojiao WangLaboratory of Cardiovascular Diseases, Regenerative Medicine Research Center, West China Hospital, Sichuan University, Chengdu 610041, China.
Song LeiDepartment of Pathology, West China Hospital, Sichuan University, Chengdu 610041, China.
Lixing YuanPublic Laboratory of West China Second University Hospital, Sichuan University, Chengdu 610041, China.ORCID 0000-0002-4435-3225
Xiaojing LiuDepartment of Cardiology, West China Hospital, Sichuan University, Chengdu 610041, China.ORCID 0000-0002-2066-7078
Sichuan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mitofusin-2 (Mfn2) is a key outer mitochondrial membrane protein, which maintains normal mitochondrial dynamics and function. However, its role in cardiac fibroblast activation remains poorly understood. In the present study, a rat model of transverse aortic constriction (TAC) was established to observe the cardiac fibroblast activation

Indexed as

Activating Transcription Factor 4AnimalsFibroblastsGTP PhosphohydrolasesMitochondrial ProteinsRatsReactive Oxygen SpeciesSignal TransductionActivating Transcription Factor 4Atf4 protein, ratGTP PhosphohydrolasesMfn2 protein, ratMitochondrial ProteinsReactive Oxygen Species

Identifiers

PMID31178957
PMCPMC6501253
OpenAlexW2940090888

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.