Evidence map›Paper›PMID 31178863›Full record

ArticleFrontiers in immunology2019

Co- but not Sequential Infection of DCs Boosts Their HIV-Specific CTL-Stimulatory Capacity.

Manuela Schönfeld, Ulla Knackmuss, Parul Chandorkar, Paul Hörtnagl, Thomas John Hope, Arnaud Moris, Rosa Bellmann-Weiler, Cornelia Lass-Flörl, Wilfried Posch, Doris Wilflingseder

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 96% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Manuela SchönfeldDivision of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria.
Ulla KnackmussDivision of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria.
Parul ChandorkarDivision of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria.
Paul HörtnaglCentral Institute for Blood Transfusion and Immunological Department, Medical University of Innsbruck, Innsbruck, Austria.
Thomas John HopeDepartment of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.
Arnaud MorisSorbonne Université, INSERM, CNRS, Center for Immunology and Microbial Infections - CIMI-Paris, Paris, France.
Rosa Bellmann-WeilerDepartment of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria.
Cornelia Lass-FlörlDivision of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria.
Wilfried PoschDivision of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria.
Doris WilflingsederDivision of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria.
Innsbruck Medical University · ATNorthwestern University · USUniversité Paris-Sud · FR

Funding

LC: HIV Vaccine Trials NetworkUM1AI068618 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Margaret Juliana McElrath · 2011 to 2026
$483.6M
Austrian Science Fund FWF P 33510NIAID NIH HHS UM1 AI068618
6 · The paper itself

Abstract

Pathogenic bacteria and their microbial products activate dendritic cells (DCs) at mucosal surfaces during sexually transmitted infections (STIs) and therefore might also differently shape DC functions during co-infection with HIV-1. We recently illustrated that complement (C) coating of HIV-1 (HIV-C), as primarily found during the acute phase of infection before appearance of HIV-specific antibodies, by-passed SAMHD1-mediated restriction in DCs and therefore mediated an increased DC activation and antiviral capacity. To determine whether the superior antiviral effects of HIV-C-exposed DCs also apply during STIs, we developed a co-infection model in which DCs were infected with

Indexed as

BiomarkersDendritic CellsHIV-1HIV InfectionsHLA-DR AntigensHumansLymphocyte ActivationT-Cell Antigen Receptor SpecificityT-Lymphocytes, CytotoxicVirus InternalizationVirus ReplicationBiomarkersHLA-DR AntigenscomplementCTLdendritic cellHIV-1STIs

Identifiers

PMID31178863
PMCPMC6542955
OpenAlexW2945674116

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.