Evidence map›Paper›PMID 31178860›Full record

ArticleFrontiers in immunology2019

Systems Immunology Characterization of Novel Vaccine Formulations for

Anneleen M F Matthijs, Gaël Auray, Virginie Jakob, Obdulio García-Nicolás, Roman O Braun, Irene Keller, Rémy Bruggman, Bert Devriendt, Filip Boyen, Carlos A Guzman and 6 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 3 countries.

Anneleen M F MatthijsDepartment of Reproduction, Obstetrics and Herd Health, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
Gaël AurayInstitute of Virology and Immunology, Mittelhäusern, Switzerland.
Virginie JakobVaccine Formulation Laboratory, University of Lausanne, Epalinges, Switzerland.
Obdulio García-NicolásInstitute of Virology and Immunology, Mittelhäusern, Switzerland.
Roman O BraunInstitute of Virology and Immunology, Mittelhäusern, Switzerland.
Irene KellerInterfaculty Bioinformatics Unit, Swiss Institute of Bioinformatics, University of Bern, Bern, Switzerland.
Rémy BruggmanInterfaculty Bioinformatics Unit, Swiss Institute of Bioinformatics, University of Bern, Bern, Switzerland.
Bert DevriendtLaboratory of Veterinary Immunology, Department of Virology, Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
Filip BoyenDepartment of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
Carlos A GuzmanDepartment of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research, Brunswick, Germany.
Annelies MichielsDepartment of Reproduction, Obstetrics and Herd Health, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
Freddy HaesebrouckDepartment of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
Nicolas CollinVaccine Formulation Laboratory, University of Lausanne, Epalinges, Switzerland.
Christophe Barnier-QuerVaccine Formulation Laboratory, University of Lausanne, Epalinges, Switzerland.
Dominiek MaesDepartment of Reproduction, Obstetrics and Herd Health, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
Artur SummerfieldInstitute of Virology and Immunology, Mittelhäusern, Switzerland.
Ghent University · BEUniversity of Bern · CHUniversity of Lausanne · CHSIB Swiss Institute of Bioinformatics · CHHelmholtz Centre for Infection Research · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We characterized five different vaccine candidates and a commercial vaccine in terms of safety, immunogenicity and using a systems vaccinology approach, with the aim to select novel vaccine candidates against

Indexed as

AnimalsAntibodies, BacterialAntibody SpecificityBacterial VaccinesCell CycleDrug Administration RoutesDrug CompoundingGene Expression ProfilingImmunity, CellularImmunity, HumoralImmunizationImmunoglobulin GMycoplasma hyopneumoniaePneumonia of Swine, MycoplasmalSwineT-LymphocytesAntibodies, BacterialBacterial VaccinesImmunoglobulin Gbacterinsimmune responsesMycoplasma hyopneumoniaesafetytranscriptomics

Identifiers

PMID31178860
PMCPMC6543460
OpenAlexW2945095121

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.