ArticleFrontiers in synaptic neuroscience2019
Optically Induced Calcium-Dependent Gene Activation and Labeling of Active Neurons Using CaMPARI and Cal-Light.
Article in Frontiers in synaptic neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- A massively parallel CRISPR-based screening platform for modifiers of neuronal depolarization.Nature communications · 2026Article
- CaMPARI2 enables stimulus-locked whole-brain activity mapping at cellular resolution in unrestrained larval zebrafish.Frontiers in molecular neuroscience · 2026Article
- CaMPARI2 Enables Stimulus-Locked Whole-Brain Activity Mapping at Cellular Resolution in Unrestrained Larval Zebrafish.bioRxiv : the preprint server for biology · 2025Article
- Orofacial Movements: Individuality and Stereotypy When Mice Move a Single Whisker to Touch.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Cutting-edge methodologies for tagging and tracing active neuronal coding in the brain.Current opinion in neurobiology · 2025Review
- Article
- Optogenetic β cell interrogation in vivo reveals a functional hierarchy directing the CaScience advances · 2024Article
- Monitoring nutrients in plants with genetically encoded sensors: achievements and perspectives.Plant physiology · 2023Review
- Exploring the memory: existing activity-dependent tools to tag and manipulate engram cells.Frontiers in cellular neuroscience · 2023Review
- The impact of phosphorylated PTEN at threonine 366 on cortical connectivity and behaviour.Brain : a journal of neurology · 2022Article
- Efficient training approaches for optimizing behavioral performance and reducing head fixation time.PloS one · 2022Article
- DeepLabStream enables closed-loop behavioral experiments using deep learning-based markerless, real-time posture detection.Communications biology · 2021Article
- Red Photoactivatable Genetic Optical-Indicators.Frontiers in cellular neuroscience · 2020Article
- Article
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Authors and funding
11 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The advent of optogenetic methods has made it possible to use endogeneously produced molecules to image and manipulate cellular, subcellular, and synaptic activity. It has also led to the development of photoactivatable calcium-dependent indicators that mark active synapses, neurons, and circuits. Furthermore, calcium-dependent photoactivation can be used to trigger gene expression in active neurons. Here we describe two sets of protocols, one using CaMPARI and a second one using Cal-Light. CaMPARI, a calcium-modulated photoactivatable ratiometric integrator, enables rapid network-wide, tunable, all-optical functional circuit mapping. Cal-Light, a photoactivatable calcium sensor, while slower to respond than CaMPARI, has the capacity to trigger the expression of genes, including effectors, activators, indicators, or other constructs. Here we describe the rationale and provide procedures for using these two calcium-dependent constructs (1)
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