Evidence map›Paper›PMID 31178616›Full record

ArticleProceedings of SPIE--the International Society for Optical Engineering2016

Multivariate surface-based analysis of corpus callosum in patients with sickle cell disease.

Yaqiong Chai, Yi Lao, Yicen Li, Chaoran Ji, Sharon O'Neil, Yalin Wang, Natasha Lepore, John Wood

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of SPIE--the International Society for Optical Engineering, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 99% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Yaqiong ChaiCIBORG laboratory, Department of Radiology, Children's Hospital Los Angeles, CA, USA.
Yi LaoCIBORG laboratory, Department of Radiology, Children's Hospital Los Angeles, CA, USA.
Yicen LiDepartment of Electrical Engineering, University of Southern California, CA, USA.
Chaoran JiDepartment of Electrical Engineering, University of Southern California, CA, USA.
Sharon O'NeilCIBORG laboratory, Department of Radiology, Children's Hospital Los Angeles, CA, USA.
Yalin WangSchool of Computing, Informatics and Decision Systems Engineering, Arizona State University, Tempe, AZ, USA.
Natasha LeporeCIBORG laboratory, Department of Radiology, Children's Hospital Los Angeles, CA, USA.
John WoodDivision of Cardiology, Children's Hospital Los Angeles, CA, USA.
University of Southern California · USChildren's Hospital of Los Angeles · USArizona State University · US

Funding

Statistical Methods for Brain Image Registration and Tensor-Based MorphometryR21EB012177 · NIBIB · CHILDREN'S HOSPITAL OF LOS ANGELES · PI LEPORE, NATASHA · 2011 to 2012
$478k
NIBIB NIH HHS R21 EB012177
6 · The paper itself

Abstract

Sickle cell disease (SCD) is a genetic hematological disease in which the hemoglobin molecule in red blood cells is abnormal. It is closely associated with many symptoms, including pain, anemia, chest syndrome and neurocognitive impairment. One of the most debilitating symptoms is elevated risk for cerebro-vascular accidents. The corpus callosum (CC), as the largest and most prominent white matter (WM) structure in the brain, can reflect the chronic cerebrovascular damage resulting from silent strokes or infarctions in asymptomatic SCD patients. While a lot of studies have reported WM alterations in this cohort, little is known about the shape deformation of the CC. Here we perform the first surface morphometry analysis of the CC in SCD patients using four different shape metrics on T1-weighted magnetic resonance images. We detect regional surface morphological differences in the CC between 11 patients and 10 healthy control subjects. Differences are located in the genu, posterior midbody and splenium, potentially casting light on the anatomical substrates underlying neuropsychological test differences between the SCD and control groups.

Indexed as

corpus callosummultivariate tensor based morphometrysickle cell disease

Identifiers

PMID31178616
PMCPMC6554202
OpenAlexW2581816916

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.