ArticleExperimental mechanics2019
Faster Sickling Kinetics and Sickle Cell Shape Evolution during Repeated Deoxygenation and Oxygenation Cycles.
Article in Experimental mechanics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Sickle Cell Disease at a Tertiary Care Center in the Vidarbha Region of India: Protocol for a Clinical and Observational Study.JMIR research protocols · 2026Observational
- Accompanying Hemoglobin Polymerization in Red Blood Cells in Patients with Sickle Cell Disease Using Fluorescence Lifetime Imaging.International journal of molecular sciences · 2024Article
- A framework of computer vision-enhanced microfluidic approach for automated assessment of the transient sickling kinetics in sickle red blood cells.Frontiers in physics · 2024Article
- Microfluidic methods to advance mechanistic understanding and translational research in sickle cell disease.Translational research : the journal of laboratory and clinical medicine · 2022Review
- Article
- Patient-Specific Organoid and Organ-on-a-Chip: 3D Cell-Culture Meets 3D Printing and Numerical Simulation.Advanced biology · 2021Review
- Mechanical fatigue of human red blood cells.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
Corrections and comments
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Authors and funding
2 authors.
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Abstract
Kinetics of cell sickling and morphological change have been recognized as important parameters that are correlated closely with altered blood rheology and vasoocclusion in microcirculation. A microfluidic transient hypoxia assay was developed to create repeated hypoxia-normoxia cycles for real time observation of repetitive sickling and unsickling of freely suspended red blood cells (RBCs) from sickle cell disease patients. Cell sickling behavior and kinetics were found to be influenced by its previous sickling-unsickling processes accumulatively, where those sickled RBCs that had a history of sickling in a previous hypoxia cycle would sickle again in subsequent hypoxia/sickling cycles and the collective sickling kinetics became progressively faster (with reduced delay time and higher sickled fraction versus deoxygenation time). Individual sickled RBCs would sickle into drastically different shapes randomly in subsequent hypoxia/sickling cycles, however, the collective shape distribution retained similar characteristics. These observations indicate a gradual worsening trend in sickling kinetics over repeated hypoxia cycles, as well as a relatively stable collective shape characteristics within a limited number of hypoxia-normoxia cycles.
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