ArticleThe Journal of reproduction and development2019
Capacitation of mouse sperm is modulated by gamma-aminobutyric acid (GABA) concentration.
Article in The Journal of reproduction and development, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 24 citations in OpenAlex.
- Regulation of spermatozoal capacitation by serotonin.The Journal of reproduction and development · 2026Review
- Interactions among progesterone, estradiol, and γ-aminobutyric acid in rat spermatozoal hyperactivation.The Journal of reproduction and development · 2026Article
- Gut Microbial Dysbiosis and Male Reproductive Health: Current Insights and Future Directions.International journal of molecular sciences · 2026Review
- Gamma-aminobutyric acid modulates buck semen quality and sperm preservation duration in vivo and in vitro.Journal of animal science · 2026Article
- Tryptophan promotes sperm hyperactivation in hamsters via 5-hydroxytryptamine biosynthesis within sperm.The Journal of reproduction and development · 2025Article
- Protective Effects ofLife (Basel, Switzerland) · 2025Article
- Mating Increases CHST10 Activity in Rat Oviductal Mucosa to Induce the Synthesis of HNK-1 Glycoproteins: Possible Role in Sperm-Oviduct Interactions.International journal of molecular sciences · 2025Article
- Proteomics and Metabolic Characteristics of Boar Seminal Plasma Extracellular Vesicles Reveal Biomarker Candidates Related to Sperm Motility.Journal of proteome research · 2024Article
- Scriptaid is a prospective agent for improving human asthenozoospermic sample quality and fertilization rate in vitro.Asian journal of andrology · 2024Article
- FromiScience · 2024Article
- Targeted Amino Acids Profiling of Human Seminal Plasma from Teratozoospermia Patients Using LC-MS/MS.Reproductive sciences (Thousand Oaks, Calif.) · 2023Article
- Characterization of the semen, gut, and urine microbiota in patients with different semen abnormalities.Frontiers in microbiology · 2023Article
- Effects of Heat Stress on Motion Characteristics and Metabolomic Profiles of Boar Spermatozoa.Genes · 2022Article
- Gut microbiota supports male reproductionFrontiers in microbiology · 2022Review
- United States Pharmacopeia (USP) Safety Review ofNutrients · 2021Review
- High mRNA expression of GABA receptors in human sperm with oligoasthenoteratozoospermia and teratozoospermia and its association with sperm parameters and intracytoplasmic sperm injection outcomes.Clinical and experimental reproductive medicine · 2021Article
- Expression and Possible Role of Nicotinic Acetylcholine Receptor ε Subunit (AChRe) in Mouse Sperm.Biology · 2021Article
- Sperm ion channels and transporters in male fertility and infertility.Nature reviews. Urology · 2021Review
- Exogenous gamma-aminobutyric acid addition enhances porcine sperm acrosome reaction.Animal science journal = Nihon chikusan GakkaihoArticle
- High concentration of dopamine treatment may induce acceleration of human sperm motility.Reproductive medicine and biologyArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In mammals, ejaculated sperm acquire their fertilizing ability during migration through the female reproductive tract, which secretes several factors that contribute to sperm capacitation. Gamma-aminobutyric acid (GABA) is a well-known neurotransmitter in the central nervous system, but additionally enhances the sperm acrosome reaction in the rat and cow. However, the detailed effects of GABA concentration on sperm function remain unclear. In this study, we detected the presence of the GABA type A receptor (GABA A) in mouse epididymal sperm by western blot analysis and in the sperm acrosome by immunocytochemistry. We also investigated the effects of GABA on sperm fertilizing ability. We found that GABA facilitated the tyrosine phosphorylation of sperm proteins, which is an index of sperm capacitation. GABA also promoted the acrosome reaction, which was suppressed by a selective GABA A receptor antagonist. We then found that the effective GABA concentration for the acrosome reaction corresponds to sperm concentration, but we did not detect any marked effect of GABA on sperm motility using a computer-assisted sperm analysis system. Using immunohistochemistry, we also detected GABA expression in the epithelia of the mouse uterus and oviduct. Furthermore, we found that the mRNA levels of glutamate decarboxylase (Gad), which generates GABA from L-glutamate, were higher in the oviduct than in the uterus, and that Gad mRNA levels were higher at estrus than at the diestrus stage. These results indicate that the GABA concentration can act as a modulator of the acrosome reaction and sperm capacitation in the female reproductive tract.
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