Evidence map›Paper›PMID 31178503›Full record

ArticleInternal medicine (Tokyo, Japan)2019

Detection of Anti-mitochondrial Antibodies Accompanied by Drug-induced Hepatic Injury due to Atorvastatin.

Noriyuki Kuniyoshi, Hiroshi Miyakawa, Kotaro Matsumoto, Hiromichi Tsunashima, Katsunori Sekine, Takayuki Tsujikawa, Masatoshi Mabuchi, Shinpei Doi, Kentaro Kikuchi

Open access · diamondAbstract readCase Reports
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Statin-induced Liver Injury Patterns: A Clinical Review.Journal of clinical and translational hepatology · 2022
    Review
  2. Prediction of adverse drug reactions based on knowledge graph embedding.BMC medical informatics and decision making · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Noriyuki KuniyoshiDepartment of Gastroenterology, Teikyo University Mizonokuchi Hospital, Japan.
Hiroshi MiyakawaFourth Department of Internal Medicine, Teikyo University Mizonokuchi Hospital, Japan.
Kotaro MatsumotoDepartment of Gastroenterology, Teikyo University Mizonokuchi Hospital, Japan.
Hiromichi TsunashimaDepartment of Gastroenterology, Teikyo University Mizonokuchi Hospital, Japan.
Katsunori SekineDepartment of Gastroenterology, Teikyo University Mizonokuchi Hospital, Japan.
Takayuki TsujikawaDepartment of Gastroenterology, Teikyo University Mizonokuchi Hospital, Japan.
Masatoshi MabuchiDepartment of Gastroenterology, Teikyo University Mizonokuchi Hospital, Japan.
Shinpei DoiDepartment of Gastroenterology, Teikyo University Mizonokuchi Hospital, Japan.
Kentaro KikuchiFourth Department of Internal Medicine, Teikyo University Mizonokuchi Hospital, Japan.
Teikyo University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 44-year-old Japanese woman was admitted to our hospital with fatigue and an altered liver function. She had been receiving atorvastatin treatment for 10 months. Although no jaundice was seen, the patient's serum alkaline phosphatase and γ-glutamyl transpeptidase levels were markedly elevated. Based on the results of a drug-induced lymphocyte-stimulation test, her liver disease was diagnosed as atorvastatin-induced hepatic injury. Subsequently, anti-mitochondrial antibodies (AMAs) were detected in her serum; however, a liver biopsy specimen did not show the characteristic features of primary biliary cholangitis. We herein report the detection of AMAs accompanied by drug-induced hepatic injury caused by atorvastatin.

Indexed as

AdultAtorvastatinAutoantibodiesChemical and Drug Induced Liver InjuryFemaleHumansHydroxymethylglutaryl-CoA Reductase InhibitorsMitochondriaAtorvastatinAutoantibodiesHydroxymethylglutaryl-CoA Reductase Inhibitorsanti-mitochondrial antibodydrug-induced lymphocyte-stimulation teststatin-induced hepatic injury

Identifiers

PMID31178503
PMCPMC6794188
OpenAlexW2951517547

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.