ArticleStem cell reports2019
The Orphan Nuclear Receptor TLX Represses Hes1 Expression, Thereby Affecting NOTCH Signaling and Lineage Progression in the Adult SEZ.
Article in Stem cell reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Nuclear receptor TLX functions to promote cancer stemness and EMT in prostate cancer via its direct transactivation of CD44 and stem cell-regulatory transcription factors.British journal of cancer · 2024Article
- GDF15 controls primary cilia morphology and function thereby affecting progenitor proliferation.Life science alliance · 2024Article
- A novel stem cell type at the basal side of the subventricular zone maintains adult neurogenesis.EMBO reports · 2022Article
- Neurogenesis in the adult brain functionally contributes to the maintenance of chronic neuropathic pain.Scientific reports · 2021Article
- Lrig1 expression prospectively identifies stem cells in the ventricular-subventricular zone that are neurogenic throughout adult life.Neural development · 2020Article
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- Manifestations of COVID-19 in the posterior eye segment - Up-to-date.Oman journal of ophthalmologyReview
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the adult subependymal zone (SEZ), neural stem cells (NSCs) apically contacting the lateral ventricle on activation generate progenitors proliferating at the niche basal side. We here show that Tailless (TLX) coordinates NSC activation and basal progenitor proliferation by repressing the NOTCH effector Hes1. Consistent with this, besides quiescence Hes1 expression also increases on Tlx mutation. Since HES1 levels are higher at the apical SEZ, NOTCH activation is increased in Tlx
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Registered trials
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