ArticleImmunity2019
Pro-inflammatory Aorta-Associated Macrophages Are Involved in Embryonic Development of Hematopoietic Stem Cells.
Article in Immunity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
61 citing papers in PubMed.
- Macrophages in embryonic development.Nature reviews. Immunology · 2026Review
- Offspring long-term infectious morbidity following pregnancies with cervical cerclage.Archives of gynecology and obstetrics · 2026Article
- Macrophages in post-chemoradiotherapy hematopoietic injury: a double-edged sword.Cell communication and signaling : CCS · 2026Review
- Gpr171 regulates embryonic hematopoietic stem cell emergence via ERK1/2 and Notch signaling.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Macrophages in Hematopoiesis and Related Blood Diseases.Genomics, proteomics & bioinformatics · 2025Review
- Ace2 safeguards embryonic hematopoietic stem and progenitor cell production by restraining Nlrp3-mediated pyroptosis.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Bloodhounds chasing the origin of blood cells.Trends in cell biology · 2025Review
- Embryonic macrophages orchestrate niche cell homeostasis for the establishment of the definitive hematopoietic stem cell pool.Nature communications · 2025Article
- Fusion of glioma-associated mesenchymal stem/stromal cells with glioma cells promotes macrophage recruitment and M2 polarization via mCell death & disease · 2025Article
- The role of different physical exercises as an anti-aging factor in different stem cells.Biogerontology · 2025Review
- Conversion of placental hemogenic endothelial cells to hematopoietic stem and progenitor cells.Cell discovery · 2025Article
- Review
- Beyond defence: Immune architects of ovarian health and disease.Seminars in immunopathology · 2024Review
- The molecular and cellular hematopoietic stem cell specification niche.Experimental hematology · 2024Review
- IκBα controls dormancy in hematopoietic stem cells via retinoic acid during embryonic development.Nature communications · 2024Article
- A subset of megakaryocytes regulates development of hematopoietic stem cell precursors.The EMBO journal · 2024Article
- A multistep computational approach reveals a neuro-mesenchymal cell population in the embryonic hematopoietic stem cell niche.Development (Cambridge, England) · 2024Article
- Fetal liver macrophages contribute to the hematopoietic stem cell niche by controlling granulopoiesis.eLife · 2024Article
- Non-Coding RNA-Targeted Therapy: A State-of-the-Art Review.International journal of molecular sciences · 2024Review
- Autophagy regulates the maturation of hematopoietic precursors in the embryo.Nature communications · 2024Article
1 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors.
Funding
Abstract
Hematopoietic stem cells (HSCs) are generated from specialized endothelial cells of the embryonic aorta. Inflammatory factors are implicated in regulating mouse HSC development, but which cells in the aorta-gonad-mesonephros (AGM) microenvironment produce these factors is unknown. In the adult, macrophages play both pro- and anti-inflammatory roles. We sought to examine whether macrophages or other hematopoietic cells found in the embryo prior to HSC generation were involved in the AGM HSC-generative microenvironment. CyTOF analysis of CD45
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.