ArticleCurrent biology : CB2019
Figure-Ground Modulation in the Human Lateral Geniculate Nucleus Is Distinguishable from Top-Down Attention.
Article in Current biology : CB, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 42 citations in OpenAlex.
- Contrasting predictive coding and representational accounts of perceptual organization, stimulus predictability, and attentional modulation in the visual cortical hierarchy.Neuroscience of consciousness · 2026Review
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- How does orientation-tuned normalization spread across the visual field?Journal of neurophysiology · 2025Article
- Convolutional neural network models applied to neuronal responses in macaque V1 reveal limited nonlinear processing.Journal of vision · 2024Article
- Training-induced changes in population receptive field properties in visual cortex: Impact of eccentric vision training on population receptive field properties and the crowding effect.Journal of vision · 2024Article
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- High-resolution 7T fMRI reveals the visual zone of the human claustrum.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- A selection and targeting framework of cortical locations for line-scanning fMRI.Human brain mapping · 2023Article
- Rapid adaptation of primate LGN neurons to drifting grating stimulation.Journal of neurophysiology · 2023Article
- Backward masking implicates cortico-cortical recurrent processes in convex figure context effects and cortico-thalamic recurrent processes in resolving figure-ground ambiguity.Frontiers in psychology · 2023Article
- Article
- Attention differentially modulates multiunit activity in the lateral geniculate nucleus and V1 of macaque monkeys.The Journal of comparative neurology · 2022Article
- Robust effects of corticothalamic feedback and behavioral state on movie responses in mouse dLGN.eLife · 2022Article
- Early-stage visual perception impairment in schizophrenia, bottom-up and back again.Schizophrenia (Heidelberg, Germany) · 2022Review
- Article
- A source for awareness-dependent figure-ground segregation in human prefrontal cortex.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Role of Feedback Connections in Central Visual Processing.Annual review of vision science · 2020Review
- Resolving the Spatial Profile of Figure Enhancement in Human V1 through Population Receptive Field Modeling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
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4 authors at 1 institution in 1 country.
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Abstract
Nearly all of the information that reaches the primary visual cortex (V1) of the brain passes from the retina through the lateral geniculate nucleus (LGN) of the thalamus. Although the LGN's role in relaying feedforward signals from the retina to the cortex is well understood [1, 2], the functional role of the extensive feedback it receives from the cortex has remained elusive [3-6]. Here, we investigated whether corticothalamic feedback may contribute to perceptual processing in the LGN in a manner that is distinct from top-down effects of attention [7-10]. We used high-resolution fMRI at 7 Tesla to simultaneously measure responses to orientation-defined figures in the human LGN and V1. We found robust enhancement of perceptual figures throughout the early visual system, which could be distinguished from the effects of covert spatial attention [11-13]. In a second experiment, we demonstrated that figure enhancement occurred in the LGN even when the figure and surrounding background were presented dichoptically (i.e., to different eyes). As binocular integration primarily occurs in V1 [14, 15], these results implicate a mechanism of automatic, contextually sensitive feedback from binocular visual cortex underlying figure-ground modulation in the LGN. Our findings elucidate the functional mechanisms of this core function of the visual system [16-18], which allows people to segment and detect meaningful figures in complex visual environments. The involvement of the LGN in this rich, contextually informed visual processing-despite showing minimal feedforward selectivity for visual features [19, 20]-underscores the role of recurrent processing at the earliest stages of visual processing.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.