Evidence map›Paper›PMID 31178098›Full record

ReviewBiological psychiatry2019

Neurobiology of Resilience: Interface Between Mind and Body.

Flurin Cathomas, James W Murrough, Eric J Nestler, Ming-Hu Han, Scott J Russo

Open access · greenAbstract readReview
In one paragraph

Review in Biological psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 164 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
164citing papers in PubMed, 3 pooled it
15.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

164 citing papers in PubMed, 3 syntheses or guidelines pooled it, 294 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Resilience, preparedness, and distress among family caregivers of patients with advanced cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021
    Trial
  5. Trial
  6. Early Exposure to a Parent's Alcohol Use Disorder as an Adverse Childhood Experience: Neurobiological and Clinical Consequences in Adulthood.Medical science monitor : international medical journal of experimental and clinical research · 2026
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Immunity in Rodent Models of Stress.Biological psychiatry · 2026
    Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article

104 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Flurin CathomasNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York; Center for Affective Neuroscience of the Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
James W MurroughNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York; Center for Affective Neuroscience of the Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York; Mood and Anxiety Disorders Program, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York.
Eric J NestlerNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York; Center for Affective Neuroscience of the Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
Ming-Hu HanNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York; Center for Affective Neuroscience of the Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York.
Scott J RussoNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York; Center for Affective Neuroscience of the Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York. Electronic address: scott.russo@mssm.edu.
Icahn School of Medicine at Mount Sinai · USAllen Institute for Brain Science · US

Funding

REPRESSIVE HISTONE AND DNA METHYLATION IN RODENT DEPRESSION MODELSP50MH096890 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ALLIS, CHARLES DAVID · 2012 to 2021
$20.2M
Pasinetti: Project 3; Role of Microbiome in Promotion of Cognitive and Psychological Resilience (Faith)P50AT008661 · NCCIH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI PASINETTI, GIULIO MARIA · 2015 to 2019
$11.2M
Using neuroeconomics to disentangle the transcriptional mechanisms underlying resilience versus susceptibility to stressR01MH051399 · NIMH · YALE UNIVERSITY · PI NESTLER, ERIC J. · 1994 to 2023
$10.2M
ROLE OF PERIPHERAL IMMUNE-DERIVED MMP8 IN STRESS SUSCEPTIBILITYR01MH104559 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI SCOTT JAMES RUSSO · 2014 to 2026
$9.2M
Role of thalamic versus cortical inputs to nucleus accumbens in stress-related disordersR01MH090264 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI RUSSO, SCOTT JAMES · 2011 to 2020
$4.2M
Role of lateral habenula orexin receptor signaling in aggressive social behaviorR01MH114882 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI RUSSO, SCOTT JAMES · 2017 to 2021
$2.7M
Rapid and Long-Lasting Antidepressant Action by Targeting Midbrain HCN ChannelsR56MH115409 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI HAN, MING-HU · 2018 to 2018
$587k
NCCIH NIH HHS P50 AT008661NIMH NIH HHS P50 MH096890NIMH NIH HHS R01 MH051399NIMH NIH HHS R01 MH090264NIMH NIH HHS R01 MH104559NIMH NIH HHS R01 MH114882NIMH NIH HHS R56 MH115409
6 · The paper itself

Abstract

Stress-related neuropsychiatric disorders, such as major depressive disorder and posttraumatic stress disorder, exact enormous socioeconomic and individual consequences. Resilience, the process of adaptation in the face of adversity, is an important concept that is enabling the field to understand individual differences in stress responses, with the hope of harnessing this information for the development of novel therapeutics that mimic the body's natural resilience mechanisms. This review provides an update on the current state of research of the neurobiological mechanisms of stress resilience. We focus on physiological and transcriptional adaptations of specific brain circuits, the role of cellular and humoral factors of the immune system, the gut microbiota, and changes at the interface between the brain and the periphery, the blood-brain barrier. We propose viewing resilience as a process that requires the integration of multiple central and peripheral systems and that elucidating the underlying neurobiological mechanisms will ultimately lead to novel therapeutic options.

Indexed as

NeurobiologyResilience, PsychologicalAdaptation, PsychologicalBlood-Brain BarrierBrainGastrointestinal MicrobiomeHumansImmune SystemMajor Depressive DisorderPsychophysiologyStress Disorders, Post-TraumaticSynaptic TransmissionBlood-brain barrierGut microbiotaInflammationMajor depressive disorderMesolimbic reward circuitPosttraumatic stress disorderResilienceStress

Identifiers

PMID31178098
PMCPMC6717018
OpenAlexW2936176560

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.