SynthesisBiological psychiatry2020
Mapping Cortical and Subcortical Asymmetry in Obsessive-Compulsive Disorder: Findings From the ENIGMA Consortium.
Open access · goldAbstract readMeta-Analysis
In one paragraph
Synthesis in Biological psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 3 pooled it
15.1field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
54 citing papers in PubMed, 3 syntheses or guidelines pooled it, 116 citations in OpenAlex.
- Shape analysis of subcortical structures in obsessive-compulsive disorder and the relationship with comorbid anxiety, depression, and medication use: A meta-analysis by the OCD Brain Imaging Consortium.Brain and behavior · 2022Pooled it
- The thalamus and its subnuclei-a gateway to obsessive-compulsive disorder.Translational psychiatry · 2022Pooled it
- ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries.Translational psychiatry · 2020Pooled it
- Effects of short-term cognitive-coping therapy on resting-state brain function in obsessive-compulsive disorder.Brain and behavior · 2021Trial
- Variations of global brain asymmetry are associated with aging and related diseases.Science advances · 2026Article
- Subtyping OCD based on individual symptom networks: subtype-specific neural dynamics and morphometric similarity linked to molecular profiles.Molecular psychiatry · 2026Article
- Regional, functional and transcriptomic decoding of multidimensional brain structure alterations in obsessive-compulsive disorder.Nature communications · 2026Article
- Global scientific trends on neuroimaging in obsessive-compulsive disorder in the early twenty-first century: a bibliometric analysis and visualization analysis.Annals of general psychiatry · 2026Review
- Genetic and molecular factors associated with changes in structural-functional coupling in medication-free obsessive-compulsive disorder.Psychological medicine · 2026Article
- Prefrontal Structural Asymmetry Mediates Body Mass Index and Treatment Response in Major Depressive Disorder.Depression and anxiety · 2026Article
- Earlier age at onset is associated with more severe sensory phenomena in drug-naive, comorbidity-free patients with obsessive-compulsive disorder.Frontiers in psychiatry · 2026Article
- The Cortical Asymmetry Index for subtyping dementia patients.European radiology · 2025Article
- Comparison of the Correlation Between Cerebral [Molecular imaging and biology · 2025Article
- The Balance in the Head: How Developmental Factors Explain Relationships Between Brain Asymmetries and Mental Diseases.Brain sciences · 2025Review
- The universe is asymmetric, the mouse brain too.Molecular psychiatry · 2025Article
- Topological differences of striato-thalamo-cortical circuit in functional brain network between premature ejaculation patients with and without depression.Brain and behavior · 2024Article
- Epigenome Defines Aberrant Brain Laterality in Major Mental Illnesses.Brain sciences · 2024Review
- Article
- Brain asymmetries from mid- to late life and hemispheric brain age.Nature communications · 2024Article
- Exploring the multidimensional nature of repetitive and restricted behaviors and interests (RRBI) in autism: neuroanatomical correlates and clinical implications.Molecular autism · 2023Article
Corrections and comments
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Authors and funding
92 authors at 20 institutions in 19 countries.
Xiang-Zhen KongLanguage and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands. Electronic address: xiangzhen.kong@outlook.com.
Premika S W BoedhoeDepartment of Psychiatry, Amsterdam Neuroscience, Amsterdam University Medical Center, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands; Department of Anatomy and Neurosciences, Amsterdam Neuroscience, Amsterdam University Medical Center, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Yoshinari AbeDepartment of Psychiatry, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Pino AlonsoDepartment of Psychiatry, Bellvitge University Hospital, Bellvitge Biomedical Research Institute-Institut d'Investigació Biomédica de Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain; Centro de Investigación Biomédica en Red de Salud Mental-CIBERSAM, University of Barcelona, Barcelona, Spain; Department of Clinical Sciences, University of Barcelona, Barcelona, Spain.
Stephanie H AmeisThe Margaret and Wallace McCain Centre for Child, Youth and Family Mental Health, Campbell Family Mental Health Research Institute, The Centre for Addiction and Mental Health, Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, Alberta; Centre for Brain and Mental Health, The Hospital for Sick Children, Toronto, Alberta.
Paul D ArnoldMathison Centre for Mental Health Research and Education, Hotchkiss Brain Institute, Calgary, Alberta; Department of Psychiatry, Cumming School of Medicine, University of Calgary, Calgary, Alberta.
Francesca AssognaLaboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, Istituto di Ricovero e Cura a Carattere Scientifico Santa Lucia Foundation, Rome, Italy.
Justin T BakerMcLean Hopsital, Harvard Medical School, Belmont, Massachusetts.
Marcelo C BatistuzzoDepartamento e Instituto de Psiquiatria do Hospital das Clinicas, IPQ HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
Francesco BenedettiPsychiatry and Clinical Psychobiology, Division of Neuroscience, Scientific Institute Ospedale San Raffaele, Milano, Italy.
Jan C BeuckeDepartment of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany.
Irene BollettiniPsychiatry and Clinical Psychobiology, Division of Neuroscience, Scientific Institute Ospedale San Raffaele, Milano, Italy.
Anushree BoseObsessive-Compulsive Disorder Clinic, Department of Psychiatry National Institute of Mental Health and Neurosciences, Bangalore, India.
Silvia BremDepartment of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric Hospital, University of Zürich, Zürich, Switzerland; Neuroscience Center Zürich, University of Zürich and Eidgenössische Technische Hochschule Zürich, Zürich, Switzerland.
Brian P BrennanMcLean Hopsital, Harvard Medical School, Belmont, Massachusetts.
Jan BuitelaarDepartment of Cognitive Neuroscience, Radboud University, Nijmegen, The Netherlands.
Rosa CalvoDepartment of Child and Adolescent Psychiatry and Psychology, Institute of Neurosciences, Hospital Clínic Universitari, Barcelona, Spain; Department of Medicine, University of Barcelona, Universitat Autònoma de Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain.
Yuqi ChengDepartment of Psychiatry, First Affiliated Hospital of Kunming Medical University, Shanghai, People's Republic of China.
Kang Ik K ChoInstitute of Human Behavioral Medicine, Seoul National University Medical Research Center, Seoul, Republic of Korea.
Sara DallaspeziaPsychiatry and Clinical Psychobiology, Division of Neuroscience, Scientific Institute Ospedale San Raffaele, Milano, Italy.
Damiaan DenysDepartment of Psychiatry, Amsterdam Neuroscience, Amsterdam, The Netherlands; Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands.
Benjamin A ElyDepartment of Neuroscience, Graduate School of Biomedical Sciences, New York, New York.
Jamie FeusnerDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles.
Kate D FitzgeraldDepartment of Psychiatry, University of Michigan, Ann Arbor, Michigan.
Jean-Paul FoucheDepartment of Psychiatry, Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa; Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa.
Egill A FridgeirssonDepartment of Psychiatry, Amsterdam Neuroscience, Amsterdam, The Netherlands.
David C GlahnDepartment of Psychiatry, New Haven, Connecticut; Olin Neuropsychiatric Research Center, Olin Neuropsychiatry Research Center, Hartford, Connecticut.
Patricia GrunerDepartment of Psychiatry, New Haven, Connecticut.
Deniz A GürselDepartment of Neuroradiology, Technische Universität München, München, Germany; TUM-Neuroimaging Center (TUM-NIC) of Klinikum Rechts der Isar, Technische Universität München, München, Germany.
Tobias U HauserDepartment of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric Hospital, University of Zürich, Zürich, Switzerland; Max Planck UCL Centre for Computational Psychiatry and Ageing Research, University College London, London, United Kingdom; Wellcome Centre for Human Neuroimaging, University College London, London, United Kingdom.
Yoshiyuki HiranoResearch Center for Child Mental Development, Chiba University, Chiba, Japan.
Marcelo Q HoexterDepartamento e Instituto de Psiquiatria do Hospital das Clinicas, IPQ HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
Hao HuShanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
Chaim HuyserDepartment of Child and Adolescent Psychiatry, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands; De Bascule, Academic Center for Child and Adolescent Psychiatry, Amsterdam, The Netherlands.
Anthony JamesDepartment of Psychiatry, Oxford University, Oxford, United Kingdom.
Fern Jaspers-FayerUniversity of British Columbia, British Columbia Children's Hospital, Vancouver, British Columbia.
Norbert KathmannDepartment of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany.
Christian KaufmannDepartment of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany.
Kathrin KochDepartment of Neuroradiology, Technische Universität München, München, Germany; TUM-Neuroimaging Center (TUM-NIC) of Klinikum Rechts der Isar, Technische Universität München, München, Germany.
Masaru KunoResearch Center for Child Mental Development, Chiba University, Chiba, Japan.
Gerd KvaleOCD Team, Haukeland University Hospital, Bergen, Norway; Department of Clinical Psychology, University of Bergen, Bergen, Norway.
Jun Soo KwonDepartment of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea; Department of Brain and Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul, Republic of Korea.
Luisa LazaroDepartment of Child and Adolescent Psychiatry and Psychology, Institute of Neurosciences, Hospital Clínic Universitari, Barcelona, Spain; Department of Medicine, University of Barcelona, Universitat Autònoma de Barcelona, Barcelona, Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat Autònoma de Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain.
Yanni LiuDepartment of Psychiatry, University of Michigan, Ann Arbor, Michigan.
Christine LochnerSU/UCT MRC Unit on Anxiety and Stress Disorders, University of Stellenbosch, Cape Town, South Africa.
Paulo MarquesLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Braga/Guimarães, Portugal; Clinical Academic Center-Braga, Braga, Braga/Guimarães, Portugal; Life and Health Sciences Research Institute (ICVS)/3B's, PT Government Associate Laboratory, Braga/Guimarães, Portugal.
Rachel MarshColumbia University Irving Medical Center, New York State Psychiatric Institute, Columbia University, New York, New York; The Division of Child and Adolescent Psychiatry, New York State Psychiatric Institute, Columbia University, New York, New York.
Ignacio Martínez-ZalacaínDepartment of Psychiatry, Bellvitge University Hospital, Bellvitge Biomedical Research Institute-Institut d'Investigació Biomédica de Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain; Department of Clinical Sciences, University of Barcelona, Barcelona, Spain.
David Mataix-ColsDepartment of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden.
Sarah E MedlandPsychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland.
José M MenchónDepartment of Psychiatry, Bellvitge University Hospital, Bellvitge Biomedical Research Institute-Institut d'Investigació Biomédica de Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain; Centro de Investigación Biomédica en Red de Salud Mental-CIBERSAM, University of Barcelona, Barcelona, Spain; Department of Clinical Sciences, University of Barcelona, Barcelona, Spain.
Luciano MinuzziMood Disorders Clinic, St. Joseph's Healthcare, Hamilton, Ontario, Canada.
Pedro S MoreiraLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Braga/Guimarães, Portugal; Clinical Academic Center-Braga, Braga, Braga/Guimarães, Portugal; Life and Health Sciences Research Institute (ICVS)/3B's, PT Government Associate Laboratory, Braga/Guimarães, Portugal.
Astrid MorerDepartment of Child and Adolescent Psychiatry and Psychology, Institute of Neurosciences, Hospital Clínic Universitari, Barcelona, Spain; Department of Medicine, University of Barcelona, Universitat Autònoma de Barcelona, Barcelona, Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat Autònoma de Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain.
Pedro MorgadoLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Braga/Guimarães, Portugal; Clinical Academic Center-Braga, Braga, Braga/Guimarães, Portugal; Life and Health Sciences Research Institute (ICVS)/3B's, PT Government Associate Laboratory, Braga/Guimarães, Portugal.
Akiko NakagawaResearch Center for Child Mental Development, Chiba University, Chiba, Japan.
Takashi NakamaeDepartment of Psychiatry, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Tomohiro NakaoDepartment of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Janardhanan C NarayanaswamyObsessive-Compulsive Disorder Clinic, Department of Psychiatry National Institute of Mental Health and Neurosciences, Bangalore, India.
Erika L NurmiDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles.
Joseph O'NeillDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles.
Jose C ParienteMagnetic Resonance Image Core Facility, Universitat Autònoma de Barcelona, Barcelona, Spain.
Chris PerrielloMcLean Hopsital, Harvard Medical School, Belmont, Massachusetts; University of Illinois at Urbana-Champaign, Champaign, Illinois.
John PiacentiniDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles.
Fabrizio PirasLaboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, Istituto di Ricovero e Cura a Carattere Scientifico Santa Lucia Foundation, Rome, Italy.
Federica PirasLaboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, Istituto di Ricovero e Cura a Carattere Scientifico Santa Lucia Foundation, Rome, Italy.
Christopher PittengerDepartment of Psychiatry, New Haven, Connecticut.
Y C Janardhan ReddyObsessive-Compulsive Disorder Clinic, Department of Psychiatry National Institute of Mental Health and Neurosciences, Bangalore, India.
Oana Georgiana Rus-OswaldUniversity of Zürich, University Hospital Zürich; Department of Neuroradiology, Zürich, Switzerland.
Yuki SakaiDepartment of Psychiatry, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan; ATR Brain Information Communication Research Laboratory Group, Kyoto, Japan.
Joao R SatoCenter of Mathematics, Computing and Cognition, Universidade Federal do ABC, Santo Andre, Brazil.
Lianne SchmaalOrygen, The National Centre of Excellence in Youth Mental Health, Parkville, Australia; Centre for Youth Mental Health, The University of Melbourne, Melbourne, Victoria, Australia.
H Blair SimpsonColumbia University Irving Medical Center, New York State Psychiatric Institute, Columbia University, New York, New York; Center for OCD and Related Disorders, New York State Psychiatric Institute, New York, New York.
Noam SoreniPediatric OCD Consultation Service, Anxiety Treatment and Research Center, St. Joseph's Healthcare, Hamilton, Ontario, Canada.
Carles Soriano-MasDepartment of Psychiatry, Bellvitge University Hospital, Bellvitge Biomedical Research Institute-Institut d'Investigació Biomédica de Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain; Centro de Investigación Biomédica en Red de Salud Mental-CIBERSAM, University of Barcelona, Barcelona, Spain; Department of Psychobiology and Methodology of Health Sciences, Universitat Autònoma de Barcelona, Barcelona, Spain.
Gianfranco SpallettaLaboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, Istituto di Ricovero e Cura a Carattere Scientifico Santa Lucia Foundation, Rome, Italy; Beth K. and Stuart C. Yudofsky Division of Neuropsychiatry, Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Texas.
Emily R SternDepartment of Psychiatry, New York University School of Medicine, New York, New York; Nathan Kline Institute for Psychiatric Research, Orangeburg, New York.
Michael C StevensYale University School of Medicine, New Haven, Connecticut; Clinical Neuroscience and Development Laboratory, Olin Neuropsychiatry Research Center, Hartford, Connecticut.
S Evelyn StewartDepartment of Psychiatry, British Columbia Children's Hospital, Vancouver, British Columbia; Provincial Obsessive-Compulsive Disorder Program, British Columbia Children's Hospital, Vancouver, British Columbia.
Philip R SzeszkoIcahn School of Medicine at Mount Sinai, New York State Psychiatric Institute, Columbia University, New York, New York; James J. Peters VA Medical Center, New York, New York.
David F TolinYale University School of Medicine, New Haven, Connecticut; Institute of Living/Hartford Hospital, Hartford, Connecticut.
Aki TsuchiyagaitoResearch Center for Child Mental Development, Chiba University, Chiba, Japan; Laureate Institute for Brain Research, Tulsa, Oklahoma.
Daan van RooijDepartment of Cognitive Neuroscience, Radboud University, Nijmegen, The Netherlands.
Guido A van WingenDepartment of Psychiatry, Amsterdam Neuroscience, Amsterdam, The Netherlands.
Ganesan VenkatasubramanianObsessive-Compulsive Disorder Clinic, Department of Psychiatry National Institute of Mental Health and Neurosciences, Bangalore, India.
Zhen WangShanghai Mental Health Center, Shanghai, People's Republic of China; Shanghai Key Laboratory of Psychotic Disorders, Shanghai, People's Republic of China.
Je-Yeon YunYeongeon Student Support Center, Seoul National University College of Medicine, Seoul, Republic of Korea; Seoul National University Hospital, Seoul, Republic of Korea.
ENIGMA OCD Working Group
Paul M ThompsonImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of the University of Southern California, Marina del Rey, California.
Dan J SteinSU/UCT MRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa.
Odile A van den HeuvelDepartment of Psychiatry, Amsterdam Neuroscience, Amsterdam University Medical Center, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands; Department of Anatomy and Neurosciences, Amsterdam Neuroscience, Amsterdam University Medical Center, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Clyde FrancksLanguage and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands; Donders Institute for Brain, Cognition and Behavior, Radboud University, Nijmegen, The Netherlands. Electronic address: clyde.francks@mpi.nl.
Universitat Autònoma de Barcelona · ESAmsterdam Neuroscience · NLRadboud University Nijmegen · NLUniversity of California, Los Angeles · USCenter for Forensic Mental Health, Chiba University · JPHarvard University · USSeoul National University · KRBellvitge University Hospital · ESHospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo · BRHumboldt-Universität zu Berlin · DEIRCCS Ospedale San Raffaele · ITKyoto Prefectural University of Medicine · JPNational Institute of Mental Health and Neurosciences · INUniversity of Cape Town · ZAUniversity of Michigan · USFondazione Santa Lucia · ITNew Haven Public Schools · USUnited Nations University · PTUniversity of Zurich · CHColumbia University Irving Medical Center · US
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MMount Sinai Institutes for Clinical and Translational SciencesUL1TR000067 · NCATS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI SAMPSON, HUGH A · 2012 to 2014
$16.5MTRAINING THE SCIENCE OF CHILD MENTAL HEALTH TREATMENTT32MH073517 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SUMA JACOB, John C. Piacentini · 2006 to 2026
$5.2MCognitive-Behavioral Therapy & Glutametergic Neurometabolites in Pediatric OCDR01MH081864 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI O'NEILL, JOSEPH, PIACENTINI, JOHN C. · 2008 to 2012
$3.0MMount Sinai Institutes for Clinical and Translational SciencesKL2TR000069 · NCATS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI SAMPSON, HUGH A · 2012 to 2014
$2.3MIndividually targeted neuromodulation for contamination-based OCDR61MH121640 · NIMH · MCLEAN HOSPITAL · PI BRENNAN, BRIAN P. · 2021 to 2022
$2.1MCognitive-Behavioral Therapy and Glutamate in Cingulate Gyrus in OCDR01MH085900 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FEUSNER, JAMIE, O'NEILL, JOSEPH · 2011 to 2014
$1.8MFrontoparietal Network Integrity and Risk for PsychosisK23MH104515 · NIMH · MCLEAN HOSPITAL · PI BAKER, JUSTIN T · 2014 to 2018
$907kfMRI study of developing medial prefrontal cortical function in pediatric OCDK23MH082176 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FITZGERALD, KATE DIMOND · 2008 to 2012
$899kGlutamatergic Mediators of Antidepressant Response in Major DepressionK23MH092397 · NIMH · MCLEAN HOSPITAL · PI BRENNAN, BRIAN P. · 2011 to 2015
$895kDissecting Causal Reasoning Abnormalities in Obsessive-Compulsive Disorder (OCD)K23MH115206 · NIMH · YALE UNIVERSITY · PI GRUNER, PATRICIA A. · 2018 to 2021
$788kThe functioning of overlapping frontostriatal circuits in children with OCDR21MH101441 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI MARSH, RACHEL, RYNN, MOIRA ANN · 2014 to 2015
$455kNCATS NIH HHS KL2 TR000069NCATS NIH HHS UL1 TR000067NCATS NIH HHS UL1 TR001863NIMH NIH HHS K23 MH082176NIMH NIH HHS K23 MH092397NIMH NIH HHS K23 MH104515NIMH NIH HHS K23 MH115206NIMH NIH HHS R01 MH081864NIMH NIH HHS R01 MH085900NIMH NIH HHS R21 MH093889NIMH NIH HHS R21 MH101441NIMH NIH HHS R21 MH110865NIMH NIH HHS R61 MH121640NIMH NIH HHS T32 MH073517Wellcome-DBT India Alliance 500236/Z/11/ZWellcome TrustWellcome Trust 211155/Z/18/Z
Abstract
backgroundLateralized dysfunction has been suggested in obsessive-compulsive disorder (OCD). However, it is currently unclear whether OCD is characterized by abnormal patterns of brain structural asymmetry. Here we carried out what is by far the largest study of brain structural asymmetry in OCD.
methodsWe studied a collection of 16 pediatric datasets (501 patients with OCD and 439 healthy control subjects), as well as 30 adult datasets (1777 patients and 1654 control subjects) from the OCD Working Group within the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) Consortium. Asymmetries of the volumes of subcortical structures, and of measures of regional cortical thickness and surface areas, were assessed based on T1-weighted magnetic resonance imaging scans, using harmonized image analysis and quality control protocols. We investigated possible alterations of brain asymmetry in patients with OCD. We also explored potential associations of asymmetry with specific aspects of the disorder and medication status.
resultsIn the pediatric datasets, the largest case-control differences were observed for volume asymmetry of the thalamus (more leftward; Cohen's d = 0.19) and the pallidum (less leftward; d = -0.21). Additional analyses suggested putative links between these asymmetry patterns and medication status, OCD severity, or anxiety and depression comorbidities. No significant case-control differences were found in the adult datasets.
conclusionsThe results suggest subtle changes of the average asymmetry of subcortical structures in pediatric OCD, which are not detectable in adults with the disorder. These findings may reflect altered neurodevelopmental processes in OCD.
Indexed as
Obsessive-Compulsive DisorderAdultBrainBrain MappingChildHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingThalamusBrain asymmetryLateralityMega-analysisObsessive-compulsive disorderPallidumThalamus
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