Observational studyStroke2019
Influence of Intracerebral Hemorrhage Location on Outcomes in Patients With Severe Intraventricular Hemorrhage.
Observational study in Stroke, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00784134 (Clot Lysis), which is not on this map. Cited by 33 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Clot Lysis: Evaluating Accelerated Resolution of Intraventricular Hemorrhage Phase III
Who cites it
33 citing papers in PubMed, 3 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- Stereotactic Drainage Treatment is Associated with Improved Long-Term Neurological Recovery in Small-to-Moderate Volume Basal Ganglia Hemorrhages: A Systematic Review and Meta-Analysis.Neurocritical care · 2026Pooled it
- Bilateral basal ganglia hemorrhage: a systematic review of etiologies, management strategies, and clinical outcomes.Neurosurgical review · 2023Pooled it
- Pooled it
- Association of Location-Specific Perihematomal Edema with Clinical Outcomes in Deep Intracerebral Hemorrhage.Neurocritical care · 2026Article
- Radiomic hemorrhage roundness predicts outcome beyond the ICH score in deep intracerebral hemorrhage with IVH.Journal of neurology · 2026Article
- Noncontrast CT-based deep learning for predicting intracerebral hemorrhage expansion incorporating growth of intraventricular hemorrhage.Scientific reports · 2025Article
- Imaging and Clinical Prognostic Features in Lobar Versus Deep Intracerebral Hemorrhage in an Unselected Swedish Population.European journal of neurology · 2025Article
- Development and validation of a clinical-radiomics nomogram for predicting 180-day functional outcomes in patients with spontaneous thalamic hemorrhage.Neurosurgical review · 2025Article
- Clinical outcomes of the neuroendoscopic far lateral supracerebellar infratentorial approach for resection of deep brain lesions.Scientific reports · 2025Article
- Spatial Correlates of Dementia and Disability After Intracerebral Hemorrhage.Journal of the American Heart Association · 2025Article
- Predicting 90-day postoperative outcomes in spontaneous supratentorial intracerebral hemorrhage: a double-center study of clinical-radiomics integration using non-contrast CT.Frontiers in neurology · 2025Article
- Development of a risk predication model for critical care needs in patients with intracerebral hemorrhage: a retrospective cohort.BMC nursing · 2024Article
- The relationship between the extent of posterior limb of the internal capsule damage measured by non-contrast computed tomography and clinical outcomes after basal ganglia hemorrhage.Neurosurgical review · 2024Article
- Advantages of disposable portable endoscope in removing thalamic hematoma via the superior parietal lobule.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2024Article
- Association between the surgical approach and prognosis of spontaneous supratentorial deep intracerebral hemorrhage.Scientific reports · 2024Article
- Predicting neurodevelopmental outcomes in extremely preterm neonates with low-grade germinal matrix-intraventricular hemorrhage using synthetic MRI.Frontiers in neuroscience · 2024Article
- Prognostic Significance of Uric Acid Levels in Intracerebral Hemorrhage Patients.Neuropsychiatric disease and treatment · 2024Article
- Machine learning-based nomogram: integrating MRI radiomics and clinical indicators for prognostic assessment in acute ischemic stroke.Frontiers in neurology · 2024Article
- Primary Intracranial Hemorrhage: Characteristics, Distribution, Risk Factors, and Outcomes-A Comparative Study between Jewish and Arab Ethnic Groups in Northern Israel.Journal of clinical medicine · 2023Article
- Risk factors and a prediction model for the prognosis of intracerebral hemorrhage using cerebral microhemorrhage and clinical factors.Frontiers in neurology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 5 institutions in 2 countries.
Funding
Abstract
Background and Purpose- We investigated the prognostic significance of spontaneous intracerebral hemorrhage location in presence of severe intraventricular hemorrhage. Methods- We analyzed diagnostic computed tomography scans from 467/500 (excluding primary intraventricular hemorrhage) subjects from the CLEAR (Clot Lysis: Evaluating Accelerated Resolution of Intraventricular Hemorrhage) III trial. We measured intracerebral hemorrhage engagement with specific anatomic regions, and estimated association of each region with blinded assessment of dichotomized poor stroke outcomes: mortality, modified Rankin Scale score of 4 to 6, National Institutes of Health Stroke Scale score of >4, stroke impact scale score of <60, Barthel Index <86, and EuroQol visual analogue scale score of <50 and <70 at days 30 and 180, respectively, using logistic regression models. Results- Frequency of anatomic region involvement consisted of thalamus (332 lesions, 71.1% of subjects), caudate (219, 46.9%), posterior limb internal capsule (188, 40.3%), globus pallidus/putamen (127, 27.2%), anterior limb internal capsule (108, 23.1%), and lobar (29, 6.2%). Thalamic location was independently associated with mortality (days 30 and 180) and with poor outcomes on most stroke scales at day 180 on adjusted analysis. Posterior limb internal capsule and globus pallidus/putamen involvement was associated with increased odds of worse disability at days 30 and 180. Anterior limb internal capsule and caudate locations were associated with decreased mortality on days 30 and 180. Anterior limb internal capsule lesions were associated with decreased long-term morbidity. Conclusions- Acute intracerebral hemorrhage lesion topography provides important insights into anatomic correlates of mortality and functional outcomes even in severe intraventricular hemorrhage causing obstructive hydrocephalus. Models accounting for intracerebral hemorrhage location in addition to volumes may improve outcome prediction and permit stratification of benefit from aggressive acute interventions. Clinical Trial Registration- URL: https://www.clinicaltrials.gov . Unique identifier: NCT00784134.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.