Evidence map›Paper›PMID 31177942›Full record

ArticleGut microbes2020

The '

Jason M Ridlon, Saravanan Devendran, João Mp Alves, Heidi Doden, Patricia G Wolf, Gabriel V Pereira, Lindsey Ly, Alyssa Volland, Hajime Takei, Hiroshi Nittono and 12 more

Open access · goldAbstract read
In one paragraph

Article in Gut microbes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
92citing papers in PubMed, 1 pooled it
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

92 citing papers in PubMed, 1 synthesis or guideline pooled it, 137 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Review
  6. Article
  7. Review
  8. Short-chain Fatty Acids and Bile Acids Signaling in Chronic Hepatitis B.Journal of clinical and translational hepatology · 2026
    Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Pangenome Analysis ofMicroorganisms · 2025
    Article

32 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 8 institutions in 3 countries.

Jason M RidlonMicrobiome Metabolic Engineering Theme, Carl R. Woese Institute for Genomic Biology , Urbana, IL, USA.
Saravanan DevendranMicrobiome Metabolic Engineering Theme, Carl R. Woese Institute for Genomic Biology , Urbana, IL, USA.
João Mp AlvesDepartment of Parasitology, Institute of Biomedical Sciences, University of São Paulo , São Paulo, Brazil.
Heidi DodenMicrobiome Metabolic Engineering Theme, Carl R. Woese Institute for Genomic Biology , Urbana, IL, USA.
Patricia G WolfMicrobiome Metabolic Engineering Theme, Carl R. Woese Institute for Genomic Biology , Urbana, IL, USA.ORCID 0000-0003-4779-7910
Gabriel V PereiraMicrobiome Metabolic Engineering Theme, Carl R. Woese Institute for Genomic Biology , Urbana, IL, USA.ORCID 0000-0001-7937-474X
Lindsey LyMicrobiome Metabolic Engineering Theme, Carl R. Woese Institute for Genomic Biology , Urbana, IL, USA.
Alyssa VollandMicrobiome Metabolic Engineering Theme, Carl R. Woese Institute for Genomic Biology , Urbana, IL, USA.
Hajime TakeiJunshin Clinic Bile Acid Institute , Meguro-Ku, Tokyo, Japan.
Hiroshi NittonoJunshin Clinic Bile Acid Institute , Meguro-Ku, Tokyo, Japan.
Tsuyoshi MuraiSchool of Pharmaceutical Sciences, Health Sciences University of Hokkaido , Ishikari-Tobetsu, Hokkaido, Japan.
Takao KurosawaSchool of Pharmaceutical Sciences, Health Sciences University of Hokkaido , Ishikari-Tobetsu, Hokkaido, Japan.
George E ChlipalaUIC Research Resources Center, University of Illinois at Chicago , Chicago, IL, USA.
Stefan J GreenUIC Research Resources Center, University of Illinois at Chicago , Chicago, IL, USA.
Alvaro G HernandezKeck Center for Biotechnology, University of Illinois at Urbana-Champaign , Urbana, IL, USA.ORCID 0000-0002-6320-1550
Christopher J FieldsKeck Center for Biotechnology, University of Illinois at Urbana-Champaign , Urbana, IL, USA.
Christy L WrightKeck Center for Biotechnology, University of Illinois at Urbana-Champaign , Urbana, IL, USA.ORCID 0000-0002-0052-5865
Genta KakiyamaDepartment of Internal Medicine, School of Medicine, Virginia Commonwealth University , Richmond, VA, USA.
Isaac CannMicrobiome Metabolic Engineering Theme, Carl R. Woese Institute for Genomic Biology , Urbana, IL, USA.
Purna KashyapDepartment of Physiology & Biomedical Engineering, Mayo Clinic , Rochester, MN, USA.
Vance McCrackenDepartment of Physiology & Biomedical Engineering, Mayo Clinic , Rochester, MN, USA.
H Rex GaskinsDepartment of Animal Sciences, University of Illinois at Urbana-Champaign , Urbana, IL, USA.
University of Illinois Urbana-Champaign · USHealth Sciences University of Hokkaido · JPTokyo Junshin University · JPUniversity of Illinois Chicago · USMayo Clinic in Arizona · USMayo Clinic in Florida · USUniversidade de São Paulo · BRVirginia Commonwealth University · US

Funding

Mechanisms of alteration of GI physiology by gut microbesR01DK114007 · NIDDK · MAYO CLINIC ROCHESTER · PI Purna C Kashyap · 2017 to 2026
$4.7M
Cancer Health Equity Career Development ProgramT32CA057699 · NCI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Marian L. Fitzgibbon · 2018 to 2026
$3.0M
Diet modulation of bacterial sulfur & bile acid metabolism and colon cancer riskR01CA204808 · NCI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI GASKINS, REX, MUTLU, ECE A. · 2016 to 2020
$2.0M
Microbial Metabolic Toxicity Drives Colon CancerR01CA179243 · NCI · MAYO CLINIC ROCHESTER · PI CHIA, NICHOLAS · 2014 to 2018
$2.0M
NCI NIH HHS R01 CA179243NCI NIH HHS R01 CA204808NCI NIH HHS T32 CA057699NIDDK NIH HHS R01 DK114007
6 · The paper itself

Abstract

The formation of secondary bile acids by gut microbes is a current topic of considerable biomedical interest. However, a detailed understanding of the biology of anaerobic bacteria in the genus

Indexed as

MetabolomeTranscriptomeAnimalsBacteria, AnaerobicBacteroidesBile Acids and SaltsBilophilaCecumCholic AcidsClostridiumGene Expression Regulation, BacterialGenome, BacterialGenomicsGerm-Free LifeHumansMiceBile Acids and SaltsCholic Acidsbile acidclostridiumGnotobioticRNA-Seq

Identifiers

PMID31177942
PMCPMC7524365
OpenAlexW2952016927

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.