ArticleJournal of medicinal chemistry2019
Improvement of Asparagine Ethylenediamines as Anti-malarial
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In one paragraph
Article in Journal of medicinal chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 13% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Ubiquitin-proteasome system inFrontiers in medicine · 2024Pooled it
- Structure-Activity Relationship Study of Antimalarial Asparagine-Derived Proteasome Inhibitors.ACS omega · 2026Article
- Combating Malaria: Targeting the Ubiquitin-Proteasome System to Conquer Drug Resistance.Tropical medicine and infectious disease · 2025Review
- Malaria parasite cysteine and aspartic proteases as key drug targets for antimalarial therapy.Journal of molecular modeling · 2025Review
- Peptidic Boronic AcidJournal of medicinal chemistry · 2024Article
- Dual-pharmacophore artezomibs hijack the Plasmodium ubiquitin-proteasome system to kill malaria parasites while overcoming drug resistance.Cell chemical biology · 2023Article
- Mitigating the risk of antimalarial resistance via covalent dual-subunit inhibition of the Plasmodium proteasome.Cell chemical biology · 2023Article
- Discovery of Highly Selective Inhibitors of the Human Constitutive Proteasome β5c Chymotryptic Subunit.Journal of medicinal chemistry · 2023Article
- Susceptibilities of Ugandan Plasmodium falciparum Isolates to Proteasome Inhibitors.Antimicrobial agents and chemotherapy · 2022Article
- Design, Synthesis, and Optimization of Macrocyclic Peptides as Species-Selective Antimalaria Proteasome Inhibitors.Journal of medicinal chemistry · 2022Article
- Article
- Microbial proteasomes as drug targets.PLoS pathogens · 2021Review
- A Proteasome Mutation SensitizesACS infectious diseases · 2021Article
- Protease Inhibition-An Established Strategy to Combat Infectious Diseases.International journal of molecular sciences · 2021Review
- Development of a Highly Selective Plasmodium falciparum Proteasome Inhibitor with Anti-malaria Activity in Humanized Mice.Angewandte Chemie (International ed. in English) · 2021Article
- Diagnostic performance of an ultrasensitive HRP2-based malaria rapid diagnostic test kit used in surveys of afebrile people living in Southern Ghana.Malaria journal · 2021Article
- Structure-Activity Relationships of Noncovalent Immunoproteasome β5i-Selective Dipeptides.Journal of medicinal chemistry · 2020Article
- Synthesis, Structure-Activity Relationship, and Antimalarial Efficacy of 6-Chloro-2-arylvinylquinolines.Journal of medicinal chemistry · 2020Article
- Molecular Mechanisms of Drug Resistance inAnnual review of microbiology · 2020Review
- Synthesis, molecular docking, antiplasmodial and antioxidant activities of new sulfonamido-pepetide derivatives.Heliyon · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 8 institutions in 2 countries.
Wenhu ZhanDepartment of Microbiology & Immunology , Weill Cornell Medicine , 1300 York Avenue , New York , New York 10065 , United States.
Joseph VisoneDepartment of Microbiology & Immunology , Weill Cornell Medicine , 1300 York Avenue , New York , New York 10065 , United States.
Tierra OuelletteDepartment of Microbiology & Immunology , Weill Cornell Medicine , 1300 York Avenue , New York , New York 10065 , United States.
Jacob C HarrisDepartment of Microbiology & Immunology , Weill Cornell Medicine , 1300 York Avenue , New York , New York 10065 , United States.
Rong WangNMR Analytical Core Facility , Memorial Sloan Kettering Cancer Center , 1275 York Avenue , New York , New York 10065 , United States.
Hao ZhangDepartment of Microbiology & Immunology , Weill Cornell Medicine , 1300 York Avenue , New York , New York 10065 , United States.
Pradeep K SinghChemical Core Facility, Department of Biochemistry , Weill Cornell Medicine , New York , New York 10065 , United States.
John GinnTri-Institutional Therapeutics Discovery Institute , 413 E. 69th Street , New York , New York 10065 , United States.
George SukenickNMR Analytical Core Facility , Memorial Sloan Kettering Cancer Center , 1275 York Avenue , New York , New York 10065 , United States.
Tzu-Tshin WongTakeda Pharmaceutical Company Ltd. , 35 Landsdowne Street , Cambridge , Massachusetts 02139 , United States.
Judith I OkoroInfectious Diseases Research Collaboration , Kampala , Uganda.
Ryan M ScalesDepartment of Public Health , University of North Carolina , Charlotte , North Carolina 28223 , United States.
Patrick K TumwebazeInfectious Diseases Research Collaboration , Kampala , Uganda.
Philip J RosenthalDepartment of Medicine , University of California, San Francisco , San Francisco , California 94143 , United States.
Björn F C KafsackDepartment of Microbiology & Immunology , Weill Cornell Medicine , 1300 York Avenue , New York , New York 10065 , United States.
Roland A CooperDepartment of Natural Sciences and Mathematics , Dominican University of California , San Rafael , California 94901 , United States.
Peter T MeinkeTri-Institutional Therapeutics Discovery Institute , 413 E. 69th Street , New York , New York 10065 , United States.
Laura A KirkmanDepartment of Microbiology & Immunology , Weill Cornell Medicine , 1300 York Avenue , New York , New York 10065 , United States.
Gang LinDepartment of Microbiology & Immunology , Weill Cornell Medicine , 1300 York Avenue , New York , New York 10065 , United States.ORCID 0000-0003-4797-7073
Cornell University · USInfectious Diseases Research Collaboration · UGMemorial Sloan Kettering Cancer Center · USTri-Institutional Therapeutics Discovery Institute · USDominican University of California · USTakeda (United States) · USUniversity of California, San Francisco · USUniversity of North Carolina at Charlotte · US
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4MResistance of Malaria Parasites to Artemisinin-Based TherapiesR01AI075045 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROSENTHAL, PHILIP JON · 2009 to 2024
$8.4MResistance of Malaria Parasites to Artemisinin-Based Combination TherapiesR56AI075045 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROSENTHAL, PHILIP JON · 2008 to 2008
$618kNovel Inhibitors of Malaria ProteasomeR21AI123794 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI KIRKMAN, LAURA, LIN, GANG · 2017 to 2018
$466kSpecies selective dipeptide inhibitors for Mtb proteasomeR21AI101393 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI LIN, GANG · 2013 to 2014
$465kNCI NIH HHS P30 CA008748NIAID NIH HHS R01 AI075045NIAID NIH HHS R21 AI101393NIAID NIH HHS R21 AI123794NIAID NIH HHS R56 AI075045
Abstract
The
Indexed as
AntimalarialsAsparagineDrug ResistanceEthylenediaminesHumansMalaria, FalciparumMutationPlasmodium falciparumProteasome Endopeptidase ComplexProteasome InhibitorsAntimalarialsAsparagineEthylenediaminesProteasome Endopeptidase ComplexProteasome Inhibitors
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.