ArticleJournal of thrombosis and haemostasis : JTH2019
Thrombin-generating potential, plasma clot formation, and clot lysis are impaired in patients with bleeding of unknown cause.
Article in Journal of thrombosis and haemostasis : JTH, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 51 citations in OpenAlex.
- A multicenter prospective observational cohort study to improve diagnostic yield and clinical management of persons with a Bleeding Disorder of Unknown Cause (BDUC-iN study protocol).Research and practice in thrombosis and haemostasis · 2026Observational
- Abnormal whole-blood viscoelastic test results in patients with bleeding disorder of unknown cause.Blood vessels, thrombosis & hemostasis · 2026Article
- Impaired thrombin generation as a reproducible feature of bleeding disorder of unknown cause.Research and practice in thrombosis and haemostasis · 2026Article
- Estimating the Factor VIII-Equivalent Activity of Emicizumab Using Global Assays of Haemostasis.Haemophilia : the official journal of the World Federation of Hemophilia · 2025Article
- [Bleeding disorders of unknown cause : Definition, diagnostics and management in the perioperative and periprocedural setting].Die Anaesthesiologie · 2025Review
- Current Practice Regarding Bleeding Disorders of Unknown Cause in the Netherlands: A National Survey.Haemophilia : the official journal of the World Federation of Hemophilia · 2025Article
- Altered clot structure in pregnant women who will develop postpartum hemorrhage.Research and practice in thrombosis and haemostasis · 2025Article
- Enhanced Hypercoagulability Using Clot Waveform Analysis in Patients with Acute Myocardial Infarction and Acute Cerebral Infarction.Journal of clinical medicine · 2024Article
- Plasmin generation analysis in patients with bleeding disorder of unknown cause.Blood advances · 2024Article
- Bleeding disorder of unknown cause: an illustrated review on current practice, knowledge gaps, and future perspectives.Research and practice in thrombosis and haemostasis · 2024Article
- Predelivery Haemostatic Biomarkers in Women with Non-Severe Postpartum Haemorrhage.Journal of clinical medicine · 2024Article
- Fibrinogen and fibrin: synthesis, structure, and function in health and disease.Journal of thrombosis and haemostasis : JTH · 2023Review
- Investigating patients for bleeding disorders when most of the "usual" ones have been ruled out.Research and practice in thrombosis and haemostasis · 2023Article
- Health-related quality of life is impaired in bleeding disorders of unknown cause: results from the Vienna Bleeding Biobank.Research and practice in thrombosis and haemostasis · 2023Article
- Review
- Major bleeding during oral anticoagulant therapy associated with factor V activation by factor Xa.Journal of thrombosis and haemostasis : JTH · 2022Article
- Fibrinolytic assays in bleeding of unknown cause: Improvement in diagnostic yield.Research and practice in thrombosis and haemostasis · 2022Article
- Thrombin generation assays to personalize treatment in bleeding and thrombotic diseases.Frontiers in cardiovascular medicine · 2022Review
- How I treat bleeding disorder of unknown cause.Blood · 2021Article
- Thrombomodulin in patients with mild to moderate bleeding tendency.Haemophilia : the official journal of the World Federation of Hemophilia · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundIn a large proportion of patients with a mild to moderate bleeding tendency no diagnosis can be established (bleeding of unknown cause, BUC).
objectivesTo investigate possible dysfunctions in thrombin generation and plasma clot formation and lysis in patients with BUC from the Vienna Bleeding Biobank (VIBB). PATIENTS AND
methodsThrombin generation and plasma clot properties of 382 BUC patients were compared to those of 100 healthy controls and 16 patients with factor VIII (FVIII) activity ≤50%.
resultsThrombin generation was significantly impaired in BUC patients compared to healthy controls, exhibiting a prolonged lag time and time to peak and decreased maximum thrombin generation, velocity index, and area under the curve (AUC). The assessment of clot formation and lysis in BUC patients revealed a lower clot formation rate (Vmax), resulting in a longer TTP, increased absorbance (ΔAbs), and a shorter clot lysis time (CLT) than in healthy controls. Comparing patients with FVIII activity ≤ 50% to those with BUC, parameters of thrombin generation and clot formation and lysis were either stronger or comparably impaired. Bleeding severity did not correlate with parameters of thrombin generation, clot formation, or clot lysis.
conclusionPatients with BUC have an impaired hemostatic capacity reflected by a lower thrombin-generation potential, a lower clot formation rate, increased clot turbidity, and shorter clot lysis time, which might contribute to their increased bleeding tendency. Assays monitoring these parameters can alert physicians of hemostatic impairment and should be considered in situations where traditional hemostatic lab tests fail to reveal the clinical bleeding tendency.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.