ArticleJournal of Alzheimer's disease : JAD2019
Clinico-Neuropathological Findings in the Oldest Old from the Georgia Centenarian Study.
Article in Journal of Alzheimer's disease : JAD, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 31 citations in OpenAlex.
- Neuropathology in a diverse cohort of oldest-old: The LifeAfter90 study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Hainan Longevity Model, Senile Degeneration, Cognitive Disability and Healthy Longevity.Aging medicine (Milton (N.S.W)) · 2026Review
- Associations between Brain Alpha-Tocopherol Stereoisomer Profile and Hallmarks of Brain Aging in Centenarians.Antioxidants (Basel, Switzerland) · 2024Article
- Study of neuropathological changes and dementia in 100 centenarians in The 90+ Study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Article
- Ultra-Early Screening of Cognitive Decline Due to Alzheimer's Pathology.Biomedicines · 2023Review
- Age-related changes in tau and autophagy in human brain in the absence of neurodegeneration.PloS one · 2023Article
- A Perspective: Challenges in Dementia Research.Medicina (Kaunas, Lithuania) · 2022Article
- Cancer and Vascular Comorbidity Effects on Dementia Risk and Neuropathology in the Oldest-Old.Journal of Alzheimer's disease : JAD · 2022Article
- Deciphering the Link Between ERFrontiers in aging neuroscience · 2022Review
- Vascular pathology and pathogenesis of cognitive impairment and dementia in older adults.Cerebral circulation - cognition and behavior · 2022Article
- Comparative neuropathology in aging primates: A perspective.American journal of primatology · 2021Review
- Article
- Carotenoid-Rich Brain Nutrient Pattern Is Positively Correlated With Higher Cognition and Lower Depression in the Oldest Old With No Dementia.Frontiers in nutrition · 2021Article
- Neuropathological assessment of the Alzheimer spectrum.Journal of neural transmission (Vienna, Austria : 1996) · 2020Review
Corrections and comments
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Authors and funding
11 authors at 8 institutions in 1 country.
Funding
Abstract
backgroundCentenarian studies are important sources for understanding of factors that contribute to longevity and healthy aging. Clinico-neuropathological finding is a key in identifying pathology and factors contributing to age-related cognitive decline and dementia in the oldest old.
objectiveTo characterize the cross-sectional relationship between neuropathologies and measures of premortem cognitive performance in centenarians.
methodsData were acquired from 49 centenarians (≥98 years) from the Georgia Centenarian Study. Cognitive assessment from the time point closest to mortality was used (<1 year for all subjects) and scores for cognitive domains were established. Neuropathologies [cerebral atrophy, ventricular dilation, atherosclerosis, cerebral amyloid angiopathy (CAA), Lewy bodies, hippocampal sclerosis (HS), hippocampal TDP-43 proteinopathy, neuritic plaque (NP) and neurofibrillary tangle (NFT) counts, Braak staging, and National Institute on Aging-Reagan Institute (NIARI) criteria for the neuropathological diagnosis of Alzheimer's disease (AD)] were compared among subjects with different ratings of dementia. Linear regression was applied to evaluate the association between cognitive domain scores and neuropathologies.
resultsWide ranges of AD-type neuropathological changes were observed in both non-demented and demented subjects. Neocortical NFT and Braak staging were related to clinical dementia rating. Neocortical NFT and NP, Braak and NIARI staging, cerebral and ventricular atrophy, HS, CAA, and TDP-43 proteinopathy were differentially associated with poor performance in multiple cognitive domains and activities of daily living.
conclusionAD-type pathology was associated with severe dementia and poor cognition but was not the only variable that explained cognitive impairment, indicating the complexity and heterogeneity of pathophysiology of dementia in the oldest old.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.